Primary osteosarcoma of the breast during lactation: a case report and literature review
Primary osteosarcoma of the breast (POB) is an aggressive and exceedingly rare tumor, and cases with onset during lactation are extremely rare. The exact mechanism of POB development remains unclear. They may originate from totipotent mesenchymal cells in the breast stroma or may be the result of ne...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1362024/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850199965446438912 |
|---|---|
| author | Huifang Zhuo Huifang Zhuo Yubei Duan Shuangshuang Dong Shuangshuang Dong Jun Zhang Jun Zhang Zijing Wang Zijing Wang Lian Meng Lian Meng Chenyan Wang Man Li Xiaotian Yang Ning Wang Ning Wang Jianming Hu |
| author_facet | Huifang Zhuo Huifang Zhuo Yubei Duan Shuangshuang Dong Shuangshuang Dong Jun Zhang Jun Zhang Zijing Wang Zijing Wang Lian Meng Lian Meng Chenyan Wang Man Li Xiaotian Yang Ning Wang Ning Wang Jianming Hu |
| author_sort | Huifang Zhuo |
| collection | DOAJ |
| description | Primary osteosarcoma of the breast (POB) is an aggressive and exceedingly rare tumor, and cases with onset during lactation are extremely rare. The exact mechanism of POB development remains unclear. They may originate from totipotent mesenchymal cells in the breast stroma or may be the result of neoplastic transformation of prior breast lesions. Here, we present the case of a 40-year-old Chinese woman who was found with a palpable tumor measuring approximately 3 cm in diameter in her right breast while breastfeeding 4 months post-partum. The lactating woman was misdiagnosed with lactational mastitis during her initial visit to a community hospital. However, due to negative bacterial cultures and ineffective anti-infective treatment, later on the patient was taken to a more advanced hospital where a tissue biopsy was taken. The superior hospital considered that it might be a malignant tumor and performed local excision of the breast mass, leading to a final pathological diagnosis of POB. This is the first reported case of primary osteosarcoma during breastfeeding. We hope that this case report will improve readers’ understanding of the diagnosis and differential diagnosis of POB, especially for patients with atypical clinical symptoms and imaging findings, which should not be taken lightly. |
| format | Article |
| id | doaj-art-40e1fbc86c4a4a7dbbb7651c41afa340 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-40e1fbc86c4a4a7dbbb7651c41afa3402025-08-20T02:12:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.13620241362024Primary osteosarcoma of the breast during lactation: a case report and literature reviewHuifang Zhuo0Huifang Zhuo1Yubei Duan2Shuangshuang Dong3Shuangshuang Dong4Jun Zhang5Jun Zhang6Zijing Wang7Zijing Wang8Lian Meng9Lian Meng10Chenyan Wang11Man Li12Xiaotian Yang13Ning Wang14Ning Wang15Jianming Hu16Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaNational Health Commission (NHC) Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaNational Health Commission (NHC) Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaNational Health Commission (NHC) Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Function, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaNational Health Commission (NHC) Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaDepartment of Internal Medicine, Fourth People's Hospital, Urumqi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaNational Health Commission (NHC) Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education)/Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, ChinaPrimary osteosarcoma of the breast (POB) is an aggressive and exceedingly rare tumor, and cases with onset during lactation are extremely rare. The exact mechanism of POB development remains unclear. They may originate from totipotent mesenchymal cells in the breast stroma or may be the result of neoplastic transformation of prior breast lesions. Here, we present the case of a 40-year-old Chinese woman who was found with a palpable tumor measuring approximately 3 cm in diameter in her right breast while breastfeeding 4 months post-partum. The lactating woman was misdiagnosed with lactational mastitis during her initial visit to a community hospital. However, due to negative bacterial cultures and ineffective anti-infective treatment, later on the patient was taken to a more advanced hospital where a tissue biopsy was taken. The superior hospital considered that it might be a malignant tumor and performed local excision of the breast mass, leading to a final pathological diagnosis of POB. This is the first reported case of primary osteosarcoma during breastfeeding. We hope that this case report will improve readers’ understanding of the diagnosis and differential diagnosis of POB, especially for patients with atypical clinical symptoms and imaging findings, which should not be taken lightly.https://www.frontiersin.org/articles/10.3389/fonc.2024.1362024/fullbreast malignancyprimary osteosarcoma of the breastlactationpathological diagnosiscase report |
| spellingShingle | Huifang Zhuo Huifang Zhuo Yubei Duan Shuangshuang Dong Shuangshuang Dong Jun Zhang Jun Zhang Zijing Wang Zijing Wang Lian Meng Lian Meng Chenyan Wang Man Li Xiaotian Yang Ning Wang Ning Wang Jianming Hu Primary osteosarcoma of the breast during lactation: a case report and literature review Frontiers in Oncology breast malignancy primary osteosarcoma of the breast lactation pathological diagnosis case report |
| title | Primary osteosarcoma of the breast during lactation: a case report and literature review |
| title_full | Primary osteosarcoma of the breast during lactation: a case report and literature review |
| title_fullStr | Primary osteosarcoma of the breast during lactation: a case report and literature review |
| title_full_unstemmed | Primary osteosarcoma of the breast during lactation: a case report and literature review |
| title_short | Primary osteosarcoma of the breast during lactation: a case report and literature review |
| title_sort | primary osteosarcoma of the breast during lactation a case report and literature review |
| topic | breast malignancy primary osteosarcoma of the breast lactation pathological diagnosis case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1362024/full |
| work_keys_str_mv | AT huifangzhuo primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT huifangzhuo primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT yubeiduan primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT shuangshuangdong primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT shuangshuangdong primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT junzhang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT junzhang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT zijingwang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT zijingwang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT lianmeng primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT lianmeng primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT chenyanwang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT manli primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT xiaotianyang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT ningwang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT ningwang primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview AT jianminghu primaryosteosarcomaofthebreastduringlactationacasereportandliteraturereview |