Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works
In the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. Enhancing the incidence of this phenomeno...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1517147/full |
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| author | Wangcai Ren Jialing Wen Gang Guo Gang Guo Wenchao Gu Shenke Zhang Shenke Zhang Chang Liu Chang Liu Kensuke Osada Takashi Shimokawa Qiaojuan Wang Qiaojuan Wang Yue Wang Yue Wang Xuanzhang Tu Chen Li Li Sui Liqiu Ma Liqiu Ma Liqiu Ma |
| author_facet | Wangcai Ren Jialing Wen Gang Guo Gang Guo Wenchao Gu Shenke Zhang Shenke Zhang Chang Liu Chang Liu Kensuke Osada Takashi Shimokawa Qiaojuan Wang Qiaojuan Wang Yue Wang Yue Wang Xuanzhang Tu Chen Li Li Sui Liqiu Ma Liqiu Ma Liqiu Ma |
| author_sort | Wangcai Ren |
| collection | DOAJ |
| description | In the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. Enhancing the incidence of this phenomenon possesses profound significance for the investigation of metastatic cancer treatment. Currently, the underlying mechanisms of the abscopal effect remain unclear. Radiation-induced immunogenic cell death is considered one of the potential mechanisms for the abscopal effect. From this perspective, we explored how physical parameters and biological factors influence this process. Differences between patients with respect to physical factors and intrinsic biological factors that activate the immune response (acquired factors) may affect the induction of the abscopal effect. |
| format | Article |
| id | doaj-art-40dd1f97332f42ae88a363602c9759a4 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-40dd1f97332f42ae88a363602c9759a42025-01-30T09:51:55ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.15171471517147Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical worksWangcai Ren0Jialing Wen1Gang Guo2Gang Guo3Wenchao Gu4Shenke Zhang5Shenke Zhang6Chang Liu7Chang Liu8Kensuke Osada9Takashi Shimokawa10Qiaojuan Wang11Qiaojuan Wang12Yue Wang13Yue Wang14Xuanzhang Tu15Chen Li16Li Sui17Liqiu Ma18Liqiu Ma19Liqiu Ma20Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, ChinaNational Innovation Center of Radiation Application, Beijing, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, ChinaNational Innovation Center of Radiation Application, Beijing, ChinaDepartment of Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, JapanMarshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, ChinaGunma University Heavy Ion Medical Center, Maebashi, JapanDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanDepartment of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, ChinaNational Innovation Center of Radiation Application, Beijing, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, ChinaNational Innovation Center of Radiation Application, Beijing, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, ChinaChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Innovation Center of Radiation Application, Beijing, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, ChinaGunma University Heavy Ion Medical Center, Maebashi, JapanDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanIn the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. Enhancing the incidence of this phenomenon possesses profound significance for the investigation of metastatic cancer treatment. Currently, the underlying mechanisms of the abscopal effect remain unclear. Radiation-induced immunogenic cell death is considered one of the potential mechanisms for the abscopal effect. From this perspective, we explored how physical parameters and biological factors influence this process. Differences between patients with respect to physical factors and intrinsic biological factors that activate the immune response (acquired factors) may affect the induction of the abscopal effect.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1517147/fullabscopal effectphysical parametersbiological factorsradiotherapyimmunogenic cell death |
| spellingShingle | Wangcai Ren Jialing Wen Gang Guo Gang Guo Wenchao Gu Shenke Zhang Shenke Zhang Chang Liu Chang Liu Kensuke Osada Takashi Shimokawa Qiaojuan Wang Qiaojuan Wang Yue Wang Yue Wang Xuanzhang Tu Chen Li Li Sui Liqiu Ma Liqiu Ma Liqiu Ma Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works Frontiers in Public Health abscopal effect physical parameters biological factors radiotherapy immunogenic cell death |
| title | Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works |
| title_full | Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works |
| title_fullStr | Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works |
| title_full_unstemmed | Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works |
| title_short | Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works |
| title_sort | physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy an update on preclinical works |
| topic | abscopal effect physical parameters biological factors radiotherapy immunogenic cell death |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1517147/full |
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