Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis
Infantile hypertrophic pyloric stenosis (IHPS) is a common disease in infancy. Pyloromyotomy is universally considered the treatment for IHPS; however, oral or intravenous atropine has been reappraised for the treatment of IHPS in the past 20 years. We investigated the efficacy of atropine in the me...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957216300262 |
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| author | Shu-Fen Wu Hsiang-Yu Lin Fu-Kuei Huang An-Chyi Chen Bai-Horng Su Chia-Ing Li Hung-Chih Lin |
| author_facet | Shu-Fen Wu Hsiang-Yu Lin Fu-Kuei Huang An-Chyi Chen Bai-Horng Su Chia-Ing Li Hung-Chih Lin |
| author_sort | Shu-Fen Wu |
| collection | DOAJ |
| description | Infantile hypertrophic pyloric stenosis (IHPS) is a common disease in infancy. Pyloromyotomy is universally considered the treatment for IHPS; however, oral or intravenous atropine has been reappraised for the treatment of IHPS in the past 20 years. We investigated the efficacy of atropine in the medical management of IHPS by using meta-analysis and investigated the sonographic changes of the pyloric canal, as well as the efficacy and adverse effects of atropine.
Methods: Information was retrieved from PubMed, Ovid, and MEDLINE. The efficacy and adverse effects of atropine treatment for IHPS were reviewed using the standard process of meta-analysis.
Results: Eleven articles were obtained. Five reports showed that 77 of 110 (70%) infants who were administered oral atropine benefitted by the induced remission of IHPS. Six reports showed that 288 of 345 (83.5%) patients who were treated initially with intravenous atropine then changed to oral atropine showed beneficial effects and had no serious side effects. Time to pyloric muscle normalization ranged from 5 weeks to 15 months.
Conclusion: The study results indicate that atropine is a possible alternative treatment for IHPS, particularly in infants with major concurrent disease, and is safe without obvious side effects. |
| format | Article |
| id | doaj-art-40db4eb449dd4ed6b37f1946b2af3351 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-40db4eb449dd4ed6b37f1946b2af33512025-08-20T03:06:16ZengElsevierPediatrics and Neonatology1875-95722016-12-0157651552110.1016/j.pedneo.2016.02.005Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysisShu-Fen Wu0Hsiang-Yu Lin1Fu-Kuei Huang2An-Chyi Chen3Bai-Horng Su4Chia-Ing Li5Hung-Chih Lin6Department of Pediatrics, China Medical University Children's Hospital, Taichung, TaiwanDepartment of Pediatrics, China Medical University Children's Hospital, Taichung, TaiwanDepartment of Pediatrics, China Medical University Children's Hospital, Taichung, TaiwanDepartment of Pediatrics, China Medical University Children's Hospital, Taichung, TaiwanDepartment of Pediatrics, China Medical University Children's Hospital, Taichung, TaiwanSchool of Medicine, China Medical University, Taichung, TaiwanDepartment of Pediatrics, China Medical University Children's Hospital, Taichung, TaiwanInfantile hypertrophic pyloric stenosis (IHPS) is a common disease in infancy. Pyloromyotomy is universally considered the treatment for IHPS; however, oral or intravenous atropine has been reappraised for the treatment of IHPS in the past 20 years. We investigated the efficacy of atropine in the medical management of IHPS by using meta-analysis and investigated the sonographic changes of the pyloric canal, as well as the efficacy and adverse effects of atropine. Methods: Information was retrieved from PubMed, Ovid, and MEDLINE. The efficacy and adverse effects of atropine treatment for IHPS were reviewed using the standard process of meta-analysis. Results: Eleven articles were obtained. Five reports showed that 77 of 110 (70%) infants who were administered oral atropine benefitted by the induced remission of IHPS. Six reports showed that 288 of 345 (83.5%) patients who were treated initially with intravenous atropine then changed to oral atropine showed beneficial effects and had no serious side effects. Time to pyloric muscle normalization ranged from 5 weeks to 15 months. Conclusion: The study results indicate that atropine is a possible alternative treatment for IHPS, particularly in infants with major concurrent disease, and is safe without obvious side effects.http://www.sciencedirect.com/science/article/pii/S1875957216300262atropineinfantile hypertrophic pyloric stenosispyloromyotomy |
| spellingShingle | Shu-Fen Wu Hsiang-Yu Lin Fu-Kuei Huang An-Chyi Chen Bai-Horng Su Chia-Ing Li Hung-Chih Lin Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis Pediatrics and Neonatology atropine infantile hypertrophic pyloric stenosis pyloromyotomy |
| title | Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis |
| title_full | Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis |
| title_fullStr | Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis |
| title_full_unstemmed | Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis |
| title_short | Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis |
| title_sort | efficacy of medical treatment for infantile hypertrophic pyloric stenosis a meta analysis |
| topic | atropine infantile hypertrophic pyloric stenosis pyloromyotomy |
| url | http://www.sciencedirect.com/science/article/pii/S1875957216300262 |
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