Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations
We present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when vi...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/3673159 |
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| author | Julie M. Hall Matthew J. Georgiades Deborah A. Hammond Xiaoting Feng Ahmed A. Moustafa Simon J. G. Lewis Gabrielle Todd |
| author_facet | Julie M. Hall Matthew J. Georgiades Deborah A. Hammond Xiaoting Feng Ahmed A. Moustafa Simon J. G. Lewis Gabrielle Todd |
| author_sort | Julie M. Hall |
| collection | DOAJ |
| description | We present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD. |
| format | Article |
| id | doaj-art-40daa8e7aa4d42e6a3fe613df070db06 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-40daa8e7aa4d42e6a3fe613df070db062025-02-03T01:00:54ZengWileyCase Reports in Neurological Medicine2090-66682090-66762017-01-01201710.1155/2017/36731593673159Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease DurationsJulie M. Hall0Matthew J. Georgiades1Deborah A. Hammond2Xiaoting Feng3Ahmed A. Moustafa4Simon J. G. Lewis5Gabrielle Todd6Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, AustraliaParkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, AustraliaParkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, AustraliaParkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, AustraliaSchool of Social Sciences and Psychology, Western Sydney University, Horsley Road & Bullecourt Road, Milperra, NSW 2214, AustraliaParkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, AustraliaSchool of Pharmacy and Medical Sciences and Sansom Institute for Health Research, University of South Australia, P.O. Box 2471, Adelaide, SA 5001, AustraliaWe present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.http://dx.doi.org/10.1155/2017/3673159 |
| spellingShingle | Julie M. Hall Matthew J. Georgiades Deborah A. Hammond Xiaoting Feng Ahmed A. Moustafa Simon J. G. Lewis Gabrielle Todd Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations Case Reports in Neurological Medicine |
| title | Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations |
| title_full | Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations |
| title_fullStr | Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations |
| title_full_unstemmed | Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations |
| title_short | Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations |
| title_sort | hyperechogenicity of the substantia nigra in parkinson s disease insights from two brothers with markedly different disease durations |
| url | http://dx.doi.org/10.1155/2017/3673159 |
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