Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital
Introduction: Various adjuvant therapies have been developed to prolong intra and postoperative analgesia. A comparative study was conducted to evaluate the onset, maximum level, and duration of motor and sensory block, as well as the duration of analgesia, side effects like hypotension, bradycardia...
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Tabriz University of Medical Sciences Press
2024-12-01
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| Series: | Journal of Research in Clinical Medicine |
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| Online Access: | https://jrcm.tbzmed.ac.ir/PDF/jrcm-12-38.pdf |
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| author | Lavanya Bachula Nallolla Rahul Dev P.V. Shiva Sunil Kumar Cherukuri |
| author_facet | Lavanya Bachula Nallolla Rahul Dev P.V. Shiva Sunil Kumar Cherukuri |
| author_sort | Lavanya Bachula |
| collection | DOAJ |
| description | Introduction: Various adjuvant therapies have been developed to prolong intra and postoperative analgesia. A comparative study was conducted to evaluate the onset, maximum level, and duration of motor and sensory block, as well as the duration of analgesia, side effects like hypotension, bradycardia, sedation, and respiratory depression in patients undergoing elective lower segment caesarean section (LSCS). Methods: The study included 60 patients, divided in to two groups to receive intrathecal hyperbaric bupivacaine (0.5%) in combination with nalbuphine (0.8 mg) (group A) and intrathecal hyperbaric bupivacaine alone (group B). Demographic data, onset of sensory and motor block, regression of motor block, duration of analgesia, hemodynamic changes, and side effects during the procedure were recorded. Results: A statistically significant difference was observed in time of onset of sensory and motor block, and maximum percentage of sensory block was attained in group B (bupivacaine) with 90% of patients. Mean duration of sensory regression to S1 was attained at 120.16 minutes in group A (bupivacaine+nalbuphine). Mean duration of analgesia was attained at 203.33 minutes in group A, and haemodynamic parameters have remained below the baseline value in both the groups. Side effects during the surgery were statistically insignificant. Conclusion: Intrathecal nalbuphine (0.8 mg) is an effective adjuvant to 0.5% hyperbaric bupivacaine in subarachnoid block for patients undergoing elective LSCS. It provides prolonged postoperative analgesia without much side effects and may be used as a better alternative over other opioids. |
| format | Article |
| id | doaj-art-40d9eadef16d4a63ac8d029d3c06558d |
| institution | DOAJ |
| issn | 2717-0616 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tabriz University of Medical Sciences Press |
| record_format | Article |
| series | Journal of Research in Clinical Medicine |
| spelling | doaj-art-40d9eadef16d4a63ac8d029d3c06558d2025-08-20T02:46:20ZengTabriz University of Medical Sciences PressJournal of Research in Clinical Medicine2717-06162024-12-01121383810.34172/jrcm.34742jrcm-34742Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospitalLavanya Bachula0Nallolla Rahul Dev1P.V. Shiva2Sunil Kumar Cherukuri3Government Medical College, Sangareddy, IndiaDepartment of Anesthesiology, Yashoda Hospital, Malakpet, Hyderabad, IndiaDepartment of Anesthesiology, Niloufer Hospital, Red Hills, Osmania Medical College, Koti, Hyderabad, IndiaGovernment Medical College, Jagtial, IndiaIntroduction: Various adjuvant therapies have been developed to prolong intra and postoperative analgesia. A comparative study was conducted to evaluate the onset, maximum level, and duration of motor and sensory block, as well as the duration of analgesia, side effects like hypotension, bradycardia, sedation, and respiratory depression in patients undergoing elective lower segment caesarean section (LSCS). Methods: The study included 60 patients, divided in to two groups to receive intrathecal hyperbaric bupivacaine (0.5%) in combination with nalbuphine (0.8 mg) (group A) and intrathecal hyperbaric bupivacaine alone (group B). Demographic data, onset of sensory and motor block, regression of motor block, duration of analgesia, hemodynamic changes, and side effects during the procedure were recorded. Results: A statistically significant difference was observed in time of onset of sensory and motor block, and maximum percentage of sensory block was attained in group B (bupivacaine) with 90% of patients. Mean duration of sensory regression to S1 was attained at 120.16 minutes in group A (bupivacaine+nalbuphine). Mean duration of analgesia was attained at 203.33 minutes in group A, and haemodynamic parameters have remained below the baseline value in both the groups. Side effects during the surgery were statistically insignificant. Conclusion: Intrathecal nalbuphine (0.8 mg) is an effective adjuvant to 0.5% hyperbaric bupivacaine in subarachnoid block for patients undergoing elective LSCS. It provides prolonged postoperative analgesia without much side effects and may be used as a better alternative over other opioids.https://jrcm.tbzmed.ac.ir/PDF/jrcm-12-38.pdfbupivacainecaesarean sectionintrathecalnalbuphine |
| spellingShingle | Lavanya Bachula Nallolla Rahul Dev P.V. Shiva Sunil Kumar Cherukuri Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital Journal of Research in Clinical Medicine bupivacaine caesarean section intrathecal nalbuphine |
| title | Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital |
| title_full | Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital |
| title_fullStr | Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital |
| title_full_unstemmed | Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital |
| title_short | Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital |
| title_sort | comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital |
| topic | bupivacaine caesarean section intrathecal nalbuphine |
| url | https://jrcm.tbzmed.ac.ir/PDF/jrcm-12-38.pdf |
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