Nano-Curcumin Mitigates Doxorubicin-Induced Reproductive Toxicity via Antioxidant, Anti-Apoptosis, and SIRT1-Modulating Effects in Rat Model

Nano-Curcumin Mitigates Doxorubicin-Induced Reproductive Toxicity via Antioxidant, Anti-Apoptosis, and SIRT1-Modulating Effects in Rat Model

Background: Doxorubicin (DOX) is a potent anti-cancer agent that is widely described in cancer treatment. However, its administration is often limited by its adverse effects, particularly its testicular toxicity, which can induce infertility in male patients. DOX-induced testicular damage is due to...

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Bibliographic Details
Main Authors: Noha A. Alshuwayer, Qamraa H. Alqahtani, Marwa H. Hussein, Raeesa Mohammed, Abdulaziz Siyal, Iman H. Hasan
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Toxics
Subjects:
nanocurcumin
doxorubicin
SIRT1
apoptosis
testicular toxicity
Online Access:https://www.mdpi.com/2305-6304/13/7/574
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