Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis
To study the initial changes in the periodontal tissues in diseases of the upper gastrointestinal tract, the study of the oxidant-antioxidant balance in the gum tissue and serum of rats with experimental gastro¬duo¬denitis was conducted. Increase in MDA in homogenates of the gums and blood serum by...
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Dnipro State Medical University
2013-03-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2013/N1/08-11.pdf |
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| author | Romanenko O.H. |
| author_facet | Romanenko O.H. |
| author_sort | Romanenko O.H. |
| collection | DOAJ |
| description | To study the initial changes in the periodontal tissues in diseases of the upper gastrointestinal tract, the study of the oxidant-antioxidant balance in the gum tissue and serum of rats with experimental gastro¬duo¬denitis was conducted. Increase in MDA in homogenates of the gums and blood serum by 1,5 and 2 times, and the level of catalase by the 3,9 and 1,6 times, respectively was registered. The level of superoxide dismutase in gin¬gival tissues and serum of rats with gastroduodenitis did not changeas com¬pared to control animals. Such changes are characteristic of hypoxia state. Activation of free radical oxidation of lipids in gum homogenates is not accompanied by increased oxidative modification of proteins, which is manifested by absence of significant changes in the main marker and aldehydphenilhydrazons ketonphenilhydrazons. When malondialdehyde content in the gum tissue a blood serum of rats increases in the experiment relative intensity and compensation of antiperoxid protection is observed, leading to the formation of endogenous oxygen that keeps cells activity in hypoxic conditions. With increase of intensity of oxidative stress, obviously, decompensation of antiperoxid protection and partial loss of the barrier function by epithelial cells occurs; this increases the possibility of inflammation development in the gums. |
| format | Article |
| id | doaj-art-40c6254492e4467e9d3b26aebf1fd5e2 |
| institution | OA Journals |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-40c6254492e4467e9d3b26aebf1fd5e22025-08-20T01:47:40ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042013-03-01181811Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitisRomanenko O.H. 0SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»To study the initial changes in the periodontal tissues in diseases of the upper gastrointestinal tract, the study of the oxidant-antioxidant balance in the gum tissue and serum of rats with experimental gastro¬duo¬denitis was conducted. Increase in MDA in homogenates of the gums and blood serum by 1,5 and 2 times, and the level of catalase by the 3,9 and 1,6 times, respectively was registered. The level of superoxide dismutase in gin¬gival tissues and serum of rats with gastroduodenitis did not changeas com¬pared to control animals. Such changes are characteristic of hypoxia state. Activation of free radical oxidation of lipids in gum homogenates is not accompanied by increased oxidative modification of proteins, which is manifested by absence of significant changes in the main marker and aldehydphenilhydrazons ketonphenilhydrazons. When malondialdehyde content in the gum tissue a blood serum of rats increases in the experiment relative intensity and compensation of antiperoxid protection is observed, leading to the formation of endogenous oxygen that keeps cells activity in hypoxic conditions. With increase of intensity of oxidative stress, obviously, decompensation of antiperoxid protection and partial loss of the barrier function by epithelial cells occurs; this increases the possibility of inflammation development in the gums.http://medpers.dsma.dp.ua/issues/2013/N1/08-11.pdf: gumexperimental gastroduodenitisantioxidant system |
| spellingShingle | Romanenko O.H. Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis Medičnì Perspektivi : gum experimental gastroduodenitis antioxidant system |
| title | Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis |
| title_full | Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis |
| title_fullStr | Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis |
| title_full_unstemmed | Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis |
| title_short | Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis |
| title_sort | oxidant antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis |
| topic | : gum experimental gastroduodenitis antioxidant system |
| url | http://medpers.dsma.dp.ua/issues/2013/N1/08-11.pdf |
| work_keys_str_mv | AT romanenkooh oxidantantioxidantbalanceinthebloodandtissuesofgumoftheratswithexperimentalgastroduodenitis |