Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction
Background We aimed to examine the association between maternal urine and serum L-type fatty acid-binding protein (L-FABP) levels and preeclampsia (PE) severity and their potential as predictors of maternal and fetal deterioration following PE diagnosis.Method A prospective cohort of women with sing...
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Taylor & Francis Group
2025-12-01
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| Series: | Hypertension in Pregnancy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641955.2025.2534508 |
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| author | Daisuke Katsura Shunichiro Tsuji Shinsuke Tokoro Ayako Inatomi Nobuyuki Kita Takashi Murakami |
| author_facet | Daisuke Katsura Shunichiro Tsuji Shinsuke Tokoro Ayako Inatomi Nobuyuki Kita Takashi Murakami |
| author_sort | Daisuke Katsura |
| collection | DOAJ |
| description | Background We aimed to examine the association between maternal urine and serum L-type fatty acid-binding protein (L-FABP) levels and preeclampsia (PE) severity and their potential as predictors of maternal and fetal deterioration following PE diagnosis.Method A prospective cohort of women with singleton pregnancies diagnosed with PE was analyzed. Participants were classified into two groups based on the timing of delivery: PE-delivery (delivery within 1 week of sample collection) and PE-non-delivery (no delivery within 1 week). Urine and serum samples were collected at the time of PE diagnosis, and cases were classified based on the presence of maternal or fetal complications.Results In total, 53 singleton pregnancies were analyzed and classified into the PE-delivery (n = 32) and PE-non-delivery groups (n = 21). No significant differences in L-FABP levels were observed between severe and non-severe PE cases. However, L-FABP levels were significantly higher in cases of severe PE due to maternal factors. In the PE-delivery group, urine and serum L-FABP levels were significantly elevated in cases requiring delivery within 1 week due to maternal indications compared to the PE-non-delivery group, whereas no such differences were found in cases with fetal indications. Receiver operating characteristic analysis showed strong predictive performance of L-FABP levels for delivery within 1 week due to maternal deterioration, with areas under the curve of 0.892 (urine, cutoff: 12.3 μg/gCr) and 0.795 (serum, cutoff: 1.64 ng/mL).Conclusion Maternal urine and serum L-FABP levels are closely associated with PE severity due to maternal complications and may serve as reliable biomarkers for imminent maternal deterioration. |
| format | Article |
| id | doaj-art-40beae2a5bff48548bdb6a0083620dae |
| institution | Kabale University |
| issn | 1064-1955 1525-6065 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj-art-40beae2a5bff48548bdb6a0083620dae2025-08-20T03:32:41ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652025-12-0144110.1080/10641955.2025.2534508Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration predictionDaisuke Katsura0Shunichiro Tsuji1Shinsuke Tokoro2Ayako Inatomi3Nobuyuki Kita4Takashi Murakami5Department of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanBackground We aimed to examine the association between maternal urine and serum L-type fatty acid-binding protein (L-FABP) levels and preeclampsia (PE) severity and their potential as predictors of maternal and fetal deterioration following PE diagnosis.Method A prospective cohort of women with singleton pregnancies diagnosed with PE was analyzed. Participants were classified into two groups based on the timing of delivery: PE-delivery (delivery within 1 week of sample collection) and PE-non-delivery (no delivery within 1 week). Urine and serum samples were collected at the time of PE diagnosis, and cases were classified based on the presence of maternal or fetal complications.Results In total, 53 singleton pregnancies were analyzed and classified into the PE-delivery (n = 32) and PE-non-delivery groups (n = 21). No significant differences in L-FABP levels were observed between severe and non-severe PE cases. However, L-FABP levels were significantly higher in cases of severe PE due to maternal factors. In the PE-delivery group, urine and serum L-FABP levels were significantly elevated in cases requiring delivery within 1 week due to maternal indications compared to the PE-non-delivery group, whereas no such differences were found in cases with fetal indications. Receiver operating characteristic analysis showed strong predictive performance of L-FABP levels for delivery within 1 week due to maternal deterioration, with areas under the curve of 0.892 (urine, cutoff: 12.3 μg/gCr) and 0.795 (serum, cutoff: 1.64 ng/mL).Conclusion Maternal urine and serum L-FABP levels are closely associated with PE severity due to maternal complications and may serve as reliable biomarkers for imminent maternal deterioration.https://www.tandfonline.com/doi/10.1080/10641955.2025.2534508L-type fatty acid-binding proteinpreeclampsiafetal growth restrictionplacental insufficiency |
| spellingShingle | Daisuke Katsura Shunichiro Tsuji Shinsuke Tokoro Ayako Inatomi Nobuyuki Kita Takashi Murakami Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction Hypertension in Pregnancy L-type fatty acid-binding protein preeclampsia fetal growth restriction placental insufficiency |
| title | Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction |
| title_full | Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction |
| title_fullStr | Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction |
| title_full_unstemmed | Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction |
| title_short | Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction |
| title_sort | urine and serum l type fatty acid binding protein levels in preeclampsia a prospective cohort study on maternal deterioration prediction |
| topic | L-type fatty acid-binding protein preeclampsia fetal growth restriction placental insufficiency |
| url | https://www.tandfonline.com/doi/10.1080/10641955.2025.2534508 |
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