Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

BackgroundExcessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson’s disease (PD) that negatively impacts quality of life. Although biomarkers of brain structure, function, and neurodegeneration have been studied, their interactions in EDS remain unclear. This study explores the...

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Bibliographic Details
Main Authors: Jieyu Chen, Guoliang Jiang, Yongyun Zhu, Chunyu Liang, Chenxi Liu, Jianzhun Chen, Baiyuan Yang, Xinglong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
cortical thickness
mediation analysis
Parkinson’s disease
neurofilament light chain
excessive daytime sleepiness
functional connectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1645290/full
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