The implications of abnormal signal patterns of break-apart FISH probes used in the diagnosis of bone and soft tissue tumours

The implications of abnormal signal patterns of break-apart FISH probes used in the diagnosis of bone and soft tissue tumours

Many subtypes of bone and soft tissue tumours harbour specific chromosome translocations leading to chimeric fusion genes. The identification of these specific fusion genes is the basis of molecular diagnoses in such tumours. Break-apart FISH is a robust method that is commonly used to identify thes...

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Bibliographic Details
Main Authors: Hongtao Ye, Fitim Berisha, Evie Rowles, Emani Munasinghe, Christopher Davies, Akanksha Farswan, Nischalan Pillay
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Pathology and Oncology Research
Subjects:
FISH
abnormal signal pattern
break-apart probe
bone and soft tissue tumour
gene rearrangement
translocation
Online Access:https://www.por-journal.com/articles/10.3389/pore.2025.1612142/full
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