Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics
Abstract Prostate cancer is the second leading malignancy in males. Prostate cancer can be easily curable if it is diagnosed at an early stage. The prognosis of patients with metastatic or resistant cases can also be improved if adequately characterized with biomarkers. Prognostic and predictive bio...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-05-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02763-1 |
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| _version_ | 1850231186551472128 |
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| author | Subhayan Das Shayeri Chatterjee Ganguly Shiuli Bera Moumita Kundu |
| author_facet | Subhayan Das Shayeri Chatterjee Ganguly Shiuli Bera Moumita Kundu |
| author_sort | Subhayan Das |
| collection | DOAJ |
| description | Abstract Prostate cancer is the second leading malignancy in males. Prostate cancer can be easily curable if it is diagnosed at an early stage. The prognosis of patients with metastatic or resistant cases can also be improved if adequately characterized with biomarkers. Prognostic and predictive biomarkers are crucial for the prediction of therapeutic response of prostate cancer patients. This article discusses various diagnostic, predictive, and prognostic biomarkers for this cancer. It also highlights the limitations of existing biomarkers and the challenges in novel biomarker discovery for prostate cancer. Moreover, this article emphasizes the application of genomics and epigenomics to discover novel prostate cancer biomarkers. Recent research to explore potential biomarkers for this disease has been reviewed here. Understanding the tumor immune microenvironment is vital for adequately diagnosing tumor tissues and predicting prognosis and therapeutic outcomes. Immune checkpoint markers are also discussed here. The current status of tumor microenvironment-based research for biomarker discovery has been explained in this article, highlighting its potential for novel biomarkers that can be employed in clinical settings. Graphical abstract |
| format | Article |
| id | doaj-art-40b18c8a00d848a19dd75d99d052bfa7 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-40b18c8a00d848a19dd75d99d052bfa72025-08-20T02:03:36ZengSpringerDiscover Oncology2730-60112025-05-0116112410.1007/s12672-025-02763-1Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeuticsSubhayan Das0Shayeri Chatterjee Ganguly1Shiuli Bera2Moumita Kundu3Department of Allied Health Sciences, Brainware UniversityDepartment of Pharmaceutical Technology, Brainware UniversityDepartment of Pharmaceutical Technology, Brainware UniversityDepartment of Pharmaceutical Technology, Brainware UniversityAbstract Prostate cancer is the second leading malignancy in males. Prostate cancer can be easily curable if it is diagnosed at an early stage. The prognosis of patients with metastatic or resistant cases can also be improved if adequately characterized with biomarkers. Prognostic and predictive biomarkers are crucial for the prediction of therapeutic response of prostate cancer patients. This article discusses various diagnostic, predictive, and prognostic biomarkers for this cancer. It also highlights the limitations of existing biomarkers and the challenges in novel biomarker discovery for prostate cancer. Moreover, this article emphasizes the application of genomics and epigenomics to discover novel prostate cancer biomarkers. Recent research to explore potential biomarkers for this disease has been reviewed here. Understanding the tumor immune microenvironment is vital for adequately diagnosing tumor tissues and predicting prognosis and therapeutic outcomes. Immune checkpoint markers are also discussed here. The current status of tumor microenvironment-based research for biomarker discovery has been explained in this article, highlighting its potential for novel biomarkers that can be employed in clinical settings. Graphical abstracthttps://doi.org/10.1007/s12672-025-02763-1Prostate cancerBiomarkersTherapeuticsPrognosisDiagnosis |
| spellingShingle | Subhayan Das Shayeri Chatterjee Ganguly Shiuli Bera Moumita Kundu Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics Discover Oncology Prostate cancer Biomarkers Therapeutics Prognosis Diagnosis |
| title | Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics |
| title_full | Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics |
| title_fullStr | Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics |
| title_full_unstemmed | Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics |
| title_short | Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics |
| title_sort | advance in prostate cancer biomarker discovery bridging detection prognosis and therapeutics |
| topic | Prostate cancer Biomarkers Therapeutics Prognosis Diagnosis |
| url | https://doi.org/10.1007/s12672-025-02763-1 |
| work_keys_str_mv | AT subhayandas advanceinprostatecancerbiomarkerdiscoverybridgingdetectionprognosisandtherapeutics AT shayerichatterjeeganguly advanceinprostatecancerbiomarkerdiscoverybridgingdetectionprognosisandtherapeutics AT shiulibera advanceinprostatecancerbiomarkerdiscoverybridgingdetectionprognosisandtherapeutics AT moumitakundu advanceinprostatecancerbiomarkerdiscoverybridgingdetectionprognosisandtherapeutics |