Significant sparse polygenic risk scores across 813 traits in UK Biobank.

Significant sparse polygenic risk scores across 813 traits in UK Biobank.

We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p < 2.5 x 10-5) incremental predictive performance when compared against the covariate-on...

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Bibliographic Details
Main Authors: Yosuke Tanigawa, Junyang Qian, Guhan Venkataraman, Johanne Marie Justesen, Ruilin Li, Robert Tibshirani, Trevor Hastie, Manuel A Rivas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-03-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010105&type=printable
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