Genome-wide profiling of circulating microRNAs in adolescent idiopathic scoliosis and their relation to spinal deformity severity, and disease pathophysiology

Genome-wide profiling of circulating microRNAs in adolescent idiopathic scoliosis and their relation to spinal deformity severity, and disease pathophysiology

Abstract Adolescent Idiopathic Scoliosis (AIS) is the most common orthopedic condition requiring surgery, affecting 4% of adolescents. There is currently no proven method or prognostic test to identify symptomatic patients at risk of developing severe scoliosis who could benefit from growth-guided d...

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Main Authors: Nasrin Khatami, Iurie Caraus, Mahamuda Rahaman, Evguenia Nepotchatykh, Mohamed Elbakry, Wesam Elremaly, Anita Franco, Marie Beauséjour, Anne-Marie Laberge, Stefan Parent, Hubert Labelle, Carl-Éric Aubin, Jean Lachaine, Alain Moreau
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Adolescent idiopathic scoliosis
Circulating microRNAs
Spinal deformity severity
Disease pathophysiology
Diagnostic and prognostic biomarkers
Machine learning
Online Access:https://doi.org/10.1038/s41598-025-88985-3
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