Retinal glia in myopia: current understanding and future directions
Myopia, a major public health problem, involves axial elongation and thinning of all layers of the eye, including sclera, choroid and retina, which defocuses incoming light and thereby blurs vision. How the various populations of glia in the retina are involved in the disorder is unclear. Astrocytes...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1512988/full |
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| author | Pengfan Chen Jing Ji Xinyi Chen Jiali Zhang Xiangyi Wen Longqian Liu |
| author_facet | Pengfan Chen Jing Ji Xinyi Chen Jiali Zhang Xiangyi Wen Longqian Liu |
| author_sort | Pengfan Chen |
| collection | DOAJ |
| description | Myopia, a major public health problem, involves axial elongation and thinning of all layers of the eye, including sclera, choroid and retina, which defocuses incoming light and thereby blurs vision. How the various populations of glia in the retina are involved in the disorder is unclear. Astrocytes and Müller cells provide structural support to the retina. Astrogliosis in myopia may influence blood oxygen supply, neuronal function, and axon diameter, which in turn may affect signal conduction. Müller cells act as a sensor of mechanical stretching in myopia and trigger downstream molecular responses. Microglia, for their part, may exhibit a reactive morphology and elevated response to inflammation in myopia. This review assesses current knowledge about how myopia may involve retinal glia, and it explores directions for future research into that question. |
| format | Article |
| id | doaj-art-40ae7e1d53ac4dbc9384835b87bc0fc2 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-40ae7e1d53ac4dbc9384835b87bc0fc22025-08-20T02:34:46ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-12-011210.3389/fcell.2024.15129881512988Retinal glia in myopia: current understanding and future directionsPengfan Chen0Jing Ji1Xinyi Chen2Jiali Zhang3Xiangyi Wen4Longqian Liu5Department of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China school of Medicine, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaMyopia, a major public health problem, involves axial elongation and thinning of all layers of the eye, including sclera, choroid and retina, which defocuses incoming light and thereby blurs vision. How the various populations of glia in the retina are involved in the disorder is unclear. Astrocytes and Müller cells provide structural support to the retina. Astrogliosis in myopia may influence blood oxygen supply, neuronal function, and axon diameter, which in turn may affect signal conduction. Müller cells act as a sensor of mechanical stretching in myopia and trigger downstream molecular responses. Microglia, for their part, may exhibit a reactive morphology and elevated response to inflammation in myopia. This review assesses current knowledge about how myopia may involve retinal glia, and it explores directions for future research into that question.https://www.frontiersin.org/articles/10.3389/fcell.2024.1512988/fullmyopiaretinagliaastrocyteMüller cellsMicroglia |
| spellingShingle | Pengfan Chen Jing Ji Xinyi Chen Jiali Zhang Xiangyi Wen Longqian Liu Retinal glia in myopia: current understanding and future directions Frontiers in Cell and Developmental Biology myopia retina glia astrocyte Müller cells Microglia |
| title | Retinal glia in myopia: current understanding and future directions |
| title_full | Retinal glia in myopia: current understanding and future directions |
| title_fullStr | Retinal glia in myopia: current understanding and future directions |
| title_full_unstemmed | Retinal glia in myopia: current understanding and future directions |
| title_short | Retinal glia in myopia: current understanding and future directions |
| title_sort | retinal glia in myopia current understanding and future directions |
| topic | myopia retina glia astrocyte Müller cells Microglia |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1512988/full |
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