Management of acute oral pain using methoxyflurane: a systematic review

Aims: Acute oral pain is a leading cause of presentations to emergency care. Methoxyflurane (MTXF) is a halogen gas with significant analgesic properties at low doses. MTXF administration was reported for dental pain with controversial results. The safety and simplicity of using a recently approved...

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Main Authors: Mériaux Océane, Falguière Arthur, Lesclous Philippe, Boisramé Sylvie
Format: Article
Language:English
Published: EDP Sciences 2024-01-01
Series:Journal of Oral Medicine and Oral Surgery
Subjects:
Online Access:https://www.jomos.org/articles/mbcb/full_html/2024/04/mbcb240144/mbcb240144.html
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author Mériaux Océane
Falguière Arthur
Lesclous Philippe
Boisramé Sylvie
author_facet Mériaux Océane
Falguière Arthur
Lesclous Philippe
Boisramé Sylvie
author_sort Mériaux Océane
collection DOAJ
description Aims: Acute oral pain is a leading cause of presentations to emergency care. Methoxyflurane (MTXF) is a halogen gas with significant analgesic properties at low doses. MTXF administration was reported for dental pain with controversial results. The safety and simplicity of using a recently approved hand-held inhaler represent encouraging evidence for its application for dental pain. Thus, a systematic review was conducted with the following objectives: to determine the efficacy of MTXF in the management of acute dental pain, and to highlight the most effective procedure. Methods: This literature review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) methodology. Results: Overall, 62 publications were identified, from which 5 articles were selected for this work. The overall quality of the included studies was low with a fairly high risk of bias. In the vast majority of studies, the level of pain experienced by patients using MTXF was low to very low. However, in some circumstances, injection of an additional local anesthetic was required for complete pain relief. The occurrence of adverse effects was low. Conclusion: All of the publications highlighted the promising properties of inhaled MTXF at low doses for acute dental pain relief.
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series Journal of Oral Medicine and Oral Surgery
spelling doaj-art-40ac8e4fc2bf425e9a56f3da64d71cee2025-08-20T03:07:24ZengEDP SciencesJournal of Oral Medicine and Oral Surgery2608-13262024-01-013043410.1051/mbcb/2024032mbcb240144Management of acute oral pain using methoxyflurane: a systematic reviewMériaux Océane0Falguière Arthur1Lesclous Philippe2Boisramé Sylvie3Department of Oral Surgery, Nantes University, University Hospital of NantesDepartment of Oral Surgery Department, University Hospital of BrestDepartment of Oral Surgery, Nantes University, University Hospital of NantesDepartment of Oral Surgery Department, University Hospital of BrestAims: Acute oral pain is a leading cause of presentations to emergency care. Methoxyflurane (MTXF) is a halogen gas with significant analgesic properties at low doses. MTXF administration was reported for dental pain with controversial results. The safety and simplicity of using a recently approved hand-held inhaler represent encouraging evidence for its application for dental pain. Thus, a systematic review was conducted with the following objectives: to determine the efficacy of MTXF in the management of acute dental pain, and to highlight the most effective procedure. Methods: This literature review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) methodology. Results: Overall, 62 publications were identified, from which 5 articles were selected for this work. The overall quality of the included studies was low with a fairly high risk of bias. In the vast majority of studies, the level of pain experienced by patients using MTXF was low to very low. However, in some circumstances, injection of an additional local anesthetic was required for complete pain relief. The occurrence of adverse effects was low. Conclusion: All of the publications highlighted the promising properties of inhaled MTXF at low doses for acute dental pain relief.https://www.jomos.org/articles/mbcb/full_html/2024/04/mbcb240144/mbcb240144.htmlanalgesicmethoxyfluraneoral pain
spellingShingle Mériaux Océane
Falguière Arthur
Lesclous Philippe
Boisramé Sylvie
Management of acute oral pain using methoxyflurane: a systematic review
Journal of Oral Medicine and Oral Surgery
analgesic
methoxyflurane
oral pain
title Management of acute oral pain using methoxyflurane: a systematic review
title_full Management of acute oral pain using methoxyflurane: a systematic review
title_fullStr Management of acute oral pain using methoxyflurane: a systematic review
title_full_unstemmed Management of acute oral pain using methoxyflurane: a systematic review
title_short Management of acute oral pain using methoxyflurane: a systematic review
title_sort management of acute oral pain using methoxyflurane a systematic review
topic analgesic
methoxyflurane
oral pain
url https://www.jomos.org/articles/mbcb/full_html/2024/04/mbcb240144/mbcb240144.html
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AT lesclousphilippe managementofacuteoralpainusingmethoxyfluraneasystematicreview
AT boisramesylvie managementofacuteoralpainusingmethoxyfluraneasystematicreview