Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health

The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its...

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Main Authors: Sandra M. Sacco, Wendy E. Ward
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Osteoporosis
Online Access:http://dx.doi.org/10.4061/2010/708931
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author Sandra M. Sacco
Wendy E. Ward
author_facet Sandra M. Sacco
Wendy E. Ward
author_sort Sandra M. Sacco
collection DOAJ
description The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed.
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spelling doaj-art-40a64d56d9094da9a19b9eff2e54ff472025-02-03T01:20:14ZengWileyJournal of Osteoporosis2042-00642010-01-01201010.4061/2010/708931708931Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone HealthSandra M. Sacco0Wendy E. Ward1Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, M5S 3E2, CanadaDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, M5S 3E2, CanadaThe rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed.http://dx.doi.org/10.4061/2010/708931
spellingShingle Sandra M. Sacco
Wendy E. Ward
Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
Journal of Osteoporosis
title Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_full Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_fullStr Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_full_unstemmed Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_short Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_sort revisiting estrogen efficacy and safety for postmenopausal bone health
url http://dx.doi.org/10.4061/2010/708931
work_keys_str_mv AT sandramsacco revisitingestrogenefficacyandsafetyforpostmenopausalbonehealth
AT wendyeward revisitingestrogenefficacyandsafetyforpostmenopausalbonehealth