Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2010/708931 |
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| _version_ | 1832563422731960320 |
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| author | Sandra M. Sacco Wendy E. Ward |
| author_facet | Sandra M. Sacco Wendy E. Ward |
| author_sort | Sandra M. Sacco |
| collection | DOAJ |
| description | The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed. |
| format | Article |
| id | doaj-art-40a64d56d9094da9a19b9eff2e54ff47 |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-40a64d56d9094da9a19b9eff2e54ff472025-02-03T01:20:14ZengWileyJournal of Osteoporosis2042-00642010-01-01201010.4061/2010/708931708931Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone HealthSandra M. Sacco0Wendy E. Ward1Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, M5S 3E2, CanadaDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, M5S 3E2, CanadaThe rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed.http://dx.doi.org/10.4061/2010/708931 |
| spellingShingle | Sandra M. Sacco Wendy E. Ward Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health Journal of Osteoporosis |
| title | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
| title_full | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
| title_fullStr | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
| title_full_unstemmed | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
| title_short | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
| title_sort | revisiting estrogen efficacy and safety for postmenopausal bone health |
| url | http://dx.doi.org/10.4061/2010/708931 |
| work_keys_str_mv | AT sandramsacco revisitingestrogenefficacyandsafetyforpostmenopausalbonehealth AT wendyeward revisitingestrogenefficacyandsafetyforpostmenopausalbonehealth |