Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis
Background. Myasthenia gravis is a chronic, autoimmune disease with muscle weakness. Acetylcholinesterase inhibitors are used in the symptomatic treatment of the disease. Allergic reaction to pyridostigmine bromide is rare. In the literature, no allergic reaction to pyridostigmine bromide has...
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Hacettepe University Institute of Child Health
2023-04-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/38 |
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| author | Fatih Kaplan Erdem Topal |
| author_facet | Fatih Kaplan Erdem Topal |
| author_sort | Fatih Kaplan |
| collection | DOAJ |
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Background. Myasthenia gravis is a chronic, autoimmune disease with muscle weakness. Acetylcholinesterase inhibitors are used in the symptomatic treatment of the disease. Allergic reaction to pyridostigmine bromide is rare. In the literature, no allergic reaction to pyridostigmine bromide has been reported in the pediatric population.
Case. A 12-year-old female patient diagnosed with myasthenia gravis consulted our clinic with the complaint of urticaria due to pyridostigmine bromide. The oral challenge test performed with pyridostigmine bromide was positive. As the patient was required to be continue pyridostigmine bromide with no suitable alternatives, it was decided that the patient had to be desensitized to pyridostigmine. During and after the desensitization protocol, no reaction was observed.
Conclusions. In this report, a successful desensitization protocol for pyridostigmine bromide in a child with myasthenia gravis is discussed.
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| format | Article |
| id | doaj-art-40a5d11eaab948c598a2d1de3fb5c309 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-40a5d11eaab948c598a2d1de3fb5c3092025-08-20T02:55:38ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212023-04-0165210.24953/turkjped.2022.386Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravisFatih Kaplan0Erdem Topal1Department of Pediatric Allergy and Immunology, İnönü University Faculty of Medicine, Malatya, Türkiye.Department of Pediatric Allergy and Immunology, İnönü University Faculty of Medicine, Malatya, Türkiye. Background. Myasthenia gravis is a chronic, autoimmune disease with muscle weakness. Acetylcholinesterase inhibitors are used in the symptomatic treatment of the disease. Allergic reaction to pyridostigmine bromide is rare. In the literature, no allergic reaction to pyridostigmine bromide has been reported in the pediatric population. Case. A 12-year-old female patient diagnosed with myasthenia gravis consulted our clinic with the complaint of urticaria due to pyridostigmine bromide. The oral challenge test performed with pyridostigmine bromide was positive. As the patient was required to be continue pyridostigmine bromide with no suitable alternatives, it was decided that the patient had to be desensitized to pyridostigmine. During and after the desensitization protocol, no reaction was observed. Conclusions. In this report, a successful desensitization protocol for pyridostigmine bromide in a child with myasthenia gravis is discussed. https://turkjpediatr.org/article/view/38allergydesensitizationmyasthenia gravispyridostigmine bromide |
| spellingShingle | Fatih Kaplan Erdem Topal Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis The Turkish Journal of Pediatrics allergy desensitization myasthenia gravis pyridostigmine bromide |
| title | Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis |
| title_full | Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis |
| title_fullStr | Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis |
| title_full_unstemmed | Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis |
| title_short | Successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis |
| title_sort | successful desensitization protocol for pyridostigmine in a 12 year old patient with myasthenia gravis |
| topic | allergy desensitization myasthenia gravis pyridostigmine bromide |
| url | https://turkjpediatr.org/article/view/38 |
| work_keys_str_mv | AT fatihkaplan successfuldesensitizationprotocolforpyridostigmineina12yearoldpatientwithmyastheniagravis AT erdemtopal successfuldesensitizationprotocolforpyridostigmineina12yearoldpatientwithmyastheniagravis |