In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction
Implementation of guideline-directed medical therapy for patients with heart failure is suboptimal. The use of guideline-directed medical therapy improves minimally after heart failure hospitalisation, despite this event clearly indicating increased risk of further hospitalisation and death. In-hosp...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2022-06-01
|
| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articleindex/cfr.2022.08 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849220259172581376 |
|---|---|
| author | Zachary L Cox Shuktika Nandkeolyar Andrew J Johnson JoAnn Lindenfeld Aniket S Rali |
| author_facet | Zachary L Cox Shuktika Nandkeolyar Andrew J Johnson JoAnn Lindenfeld Aniket S Rali |
| author_sort | Zachary L Cox |
| collection | DOAJ |
| description | Implementation of guideline-directed medical therapy for patients with heart failure is suboptimal. The use of guideline-directed medical therapy improves minimally after heart failure hospitalisation, despite this event clearly indicating increased risk of further hospitalisation and death. In-hospital initiation and titration of guideline-directed medical therapies is one potential strategy to fill these gaps in care, both in the acute vulnerable period after hospital discharge and in the long term. The purpose of this article is to review the knowledge gaps in best practices of in-hospital initiation and up-titration of guideline-directed medical therapies, the benefits and risks of in-hospital initiation and post-discharge focused titration of guideline-directed medical therapies, the recent literature evaluating these practices, and propose strategies to apply these principles to the care of patients with heart failure with reduced ejection fraction. |
| format | Article |
| id | doaj-art-40a0da16631b45fbab87101bbc713b4e |
| institution | Kabale University |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-40a0da16631b45fbab87101bbc713b4e2024-12-14T16:03:43ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592022-06-01810.15420/cfr.2022.08In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection FractionZachary L Cox0Shuktika Nandkeolyar1Andrew J Johnson2JoAnn Lindenfeld3Aniket S Rali4Department of Pharmacy Practice, Lipscomb University College of Pharmacy, Nashville, TN, US; Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USDepartment of Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USImplementation of guideline-directed medical therapy for patients with heart failure is suboptimal. The use of guideline-directed medical therapy improves minimally after heart failure hospitalisation, despite this event clearly indicating increased risk of further hospitalisation and death. In-hospital initiation and titration of guideline-directed medical therapies is one potential strategy to fill these gaps in care, both in the acute vulnerable period after hospital discharge and in the long term. The purpose of this article is to review the knowledge gaps in best practices of in-hospital initiation and up-titration of guideline-directed medical therapies, the benefits and risks of in-hospital initiation and post-discharge focused titration of guideline-directed medical therapies, the recent literature evaluating these practices, and propose strategies to apply these principles to the care of patients with heart failure with reduced ejection fraction.https://www.cfrjournal.com/articleindex/cfr.2022.08 |
| spellingShingle | Zachary L Cox Shuktika Nandkeolyar Andrew J Johnson JoAnn Lindenfeld Aniket S Rali In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction Cardiac Failure Review |
| title | In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction |
| title_full | In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction |
| title_fullStr | In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction |
| title_full_unstemmed | In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction |
| title_short | In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction |
| title_sort | in hospital initiation and up titration of guideline directed medical therapies for heart failure with reduced ejection fraction |
| url | https://www.cfrjournal.com/articleindex/cfr.2022.08 |
| work_keys_str_mv | AT zacharylcox inhospitalinitiationanduptitrationofguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfraction AT shuktikanandkeolyar inhospitalinitiationanduptitrationofguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfraction AT andrewjjohnson inhospitalinitiationanduptitrationofguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfraction AT joannlindenfeld inhospitalinitiationanduptitrationofguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfraction AT aniketsrali inhospitalinitiationanduptitrationofguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfraction |