Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options
Chronic kidney disease (CKD) is considered one of the most important public health problems today. CKD is characterized by changes in kidney structure and impaired kidney function (reduced estimated glomerular filtration rate). Data show that more than 13% of the population suffers from CKD and that...
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2025-01-01
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| Series: | Arhiv za farmaciju |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2025/0004-19632502148I.pdf |
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| author | Ilić Miloš Stanić Dušanka Kravljača Milica Petrović Jelena Ivanović Ana Nedeljković Jelena Nikolašević Stojković Gorana Pešić Vesna |
| author_facet | Ilić Miloš Stanić Dušanka Kravljača Milica Petrović Jelena Ivanović Ana Nedeljković Jelena Nikolašević Stojković Gorana Pešić Vesna |
| author_sort | Ilić Miloš |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is considered one of the most important public health problems today. CKD is characterized by changes in kidney structure and impaired kidney function (reduced estimated glomerular filtration rate). Data show that more than 13% of the population suffers from CKD and that it will be the fifth leading cause of death by 2040. To date, numerous animal models for CKD have been developed. They are used to unravel the pathophysiological mechanisms of CKD development and represent a very important platform for the development of new therapeutic strategies. All animal models for CKD can be systematized in different ways, such as surgical/non-surgical models, subdivisions based on pathological changes in kidney structure or as subdivisions based on the pathophysiological mechanisms leading to the development of CKD. In surgical models, part of the kidney tissue is usually removed, while in non-surgical models, certain substances with nephrotoxic effects are used. The choice of model depends on the experimental design and the aim of the specific study. This paper provides an overview of all currently known animal models for CKD. |
| format | Article |
| id | doaj-art-409eb23aafab48fb9eaead0f8d13410d |
| institution | Kabale University |
| issn | 0004-1963 2217-8767 |
| language | srp |
| publishDate | 2025-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj-art-409eb23aafab48fb9eaead0f8d13410d2025-08-20T03:49:31ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672025-01-0175214816610.5937/arhfarm75-559080004-19632502148IAnimal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic optionsIlić Miloš0Stanić Dušanka1https://orcid.org/0000-0002-4494-5554Kravljača Milica2Petrović Jelena3https://orcid.org/0000-0002-1821-1362Ivanović Ana4Nedeljković Jelena5Nikolašević Stojković Gorana6Pešić Vesna7https://orcid.org/0000-0002-1951-7291Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaUniverzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaUniverzitet u Beogradu - Medicinski fakultet, Klinika za nefrologiju, SerbiaUniverzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaUniverzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaUniverzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaUniverzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaUniverzitet u Beogradu - Farmaceutski fakultet, Katedra za fiziologiju, Beograd, SerbiaChronic kidney disease (CKD) is considered one of the most important public health problems today. CKD is characterized by changes in kidney structure and impaired kidney function (reduced estimated glomerular filtration rate). Data show that more than 13% of the population suffers from CKD and that it will be the fifth leading cause of death by 2040. To date, numerous animal models for CKD have been developed. They are used to unravel the pathophysiological mechanisms of CKD development and represent a very important platform for the development of new therapeutic strategies. All animal models for CKD can be systematized in different ways, such as surgical/non-surgical models, subdivisions based on pathological changes in kidney structure or as subdivisions based on the pathophysiological mechanisms leading to the development of CKD. In surgical models, part of the kidney tissue is usually removed, while in non-surgical models, certain substances with nephrotoxic effects are used. The choice of model depends on the experimental design and the aim of the specific study. This paper provides an overview of all currently known animal models for CKD.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2025/0004-19632502148I.pdfchronic kidney diseaseanimal modelsnephrotoxicitypathophysiologyrodents |
| spellingShingle | Ilić Miloš Stanić Dušanka Kravljača Milica Petrović Jelena Ivanović Ana Nedeljković Jelena Nikolašević Stojković Gorana Pešić Vesna Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options Arhiv za farmaciju chronic kidney disease animal models nephrotoxicity pathophysiology rodents |
| title | Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options |
| title_full | Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options |
| title_fullStr | Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options |
| title_full_unstemmed | Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options |
| title_short | Animal models of chronic kidney disease: The missing piece of the puzzle for the development of new therapeutic options |
| title_sort | animal models of chronic kidney disease the missing piece of the puzzle for the development of new therapeutic options |
| topic | chronic kidney disease animal models nephrotoxicity pathophysiology rodents |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2025/0004-19632502148I.pdf |
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