Integrative bulk and single-cell transcriptomic analysis identifies a migrasome-associated lncRNA signature predictive of prognosis and immune landscape in clear cell renal cell carcinoma

Integrative bulk and single-cell transcriptomic analysis identifies a migrasome-associated lncRNA signature predictive of prognosis and immune landscape in clear cell renal cell carcinoma

IntroductionClear cell renal cell carcinoma (ccRCC) is characterized by high recurrence and metastasis rates, leading to poor prognosis. Migrasomes, a class of organelles mediating intercellular communication, and long noncoding RNAs (lncRNAs) both play critical roles in tumor progression; however,...

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Bibliographic Details
Main Authors: Junlin Shen, Chun Wang, Mingpeng Zhang, Bin Chen, Liwei Liu, Jing Tian, Zhiqun Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
clear cell renal cell carcinoma
migrasome
prognostic signature
tumor mutation burden
tumor immune microenvironment
drug sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638792/full
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