Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial
Background: A cerebrovascular accident results in behavioral deficits as a result of damage to the brain’s systems. The motor system is one of the most commonly affected nervous systems. Lower limb motor function is important to a person’s functional independence. Therefore, restoring lower limb mot...
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Guilan University of Medical Sciences
2025-04-01
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| Series: | Caspian Journal of Neurological Sciences |
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| Online Access: | http://cjns.gums.ac.ir/article-1-753-en.pdf |
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| author | Somaye Azarnia kamran Ezzati Alia Saberi Yaser Moaddabi Babak Bakhshayesh Eghbali |
| author_facet | Somaye Azarnia kamran Ezzati Alia Saberi Yaser Moaddabi Babak Bakhshayesh Eghbali |
| author_sort | Somaye Azarnia |
| collection | DOAJ |
| description | Background: A cerebrovascular accident results in behavioral deficits as a result of damage to the brain’s systems. The motor system is one of the most commonly affected nervous systems. Lower limb motor function is important to a person’s functional independence. Therefore, restoring lower limb motor function can be an important goal in rehabilitating patients after stroke. Scientists have shown the effects of non-invasive brain stimulation, such as tDCS, in improving the performance of stroke patients. Recently, researchers have proposed that unihemispheric dual-site anodal transcranial direct current stimulation (UHCDS a-tDCS) targeting the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) could improve the effectiveness of a-tDCS in stroke rehabilitation.
Objectives: This study aimed to examine the effect of simultaneous stimulation of two points on the function of the lower limbs of stroke patients.
Materials & Methods: This was a double-blind, randomized clinical trial. The study included 18 patients who had experienced their first chronic stroke. Participants were assigned to either experimental group 1 or group 2, with both undergoing 5 consecutive sessions of a-tDCS. In experimental group 1, patients received active a-tDCS targeting both the M1 and DLPFC, while in experimental group 2, patients received a-tDCS to the M1 and sham stimulation to the DLPFC. Lower limb motor function was assessed using the Fugl-Meyer and time up-and-go test. Assessments were made before and after 5 sessions.
Results: The results indicate that following 5 sessions of a-tDCSM1-DLPFC, mobility and functional strength are better than a-tDCSM1 (P=0.04 and P=0.07).
Conclusion: Dual site stimulation a-tDCSM1-DLPFC can further improve balance in patients with chronic stroke. |
| format | Article |
| id | doaj-art-4095cb4e71b84646bfd0909bf14f357c |
| institution | DOAJ |
| issn | 2423-4818 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj-art-4095cb4e71b84646bfd0909bf14f357c2025-08-20T03:17:35ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182025-04-01112172179Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical TrialSomaye Azarnia0kamran Ezzati1Alia Saberi2Yaser Moaddabi3Babak Bakhshayesh Eghbali4 Department of Physiotherapy, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Physiotherapy, Neuroscience Research Center, School of Medicine, Trauma Institute, Poorsina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Department of Neurology, Neuroscience Research Center, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran Department of Neurology, Faculty of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Department of Physiotherapy, Neuroscience Research Center, School of Medicine, Trauma Institute, Poorsina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Background: A cerebrovascular accident results in behavioral deficits as a result of damage to the brain’s systems. The motor system is one of the most commonly affected nervous systems. Lower limb motor function is important to a person’s functional independence. Therefore, restoring lower limb motor function can be an important goal in rehabilitating patients after stroke. Scientists have shown the effects of non-invasive brain stimulation, such as tDCS, in improving the performance of stroke patients. Recently, researchers have proposed that unihemispheric dual-site anodal transcranial direct current stimulation (UHCDS a-tDCS) targeting the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) could improve the effectiveness of a-tDCS in stroke rehabilitation. Objectives: This study aimed to examine the effect of simultaneous stimulation of two points on the function of the lower limbs of stroke patients. Materials & Methods: This was a double-blind, randomized clinical trial. The study included 18 patients who had experienced their first chronic stroke. Participants were assigned to either experimental group 1 or group 2, with both undergoing 5 consecutive sessions of a-tDCS. In experimental group 1, patients received active a-tDCS targeting both the M1 and DLPFC, while in experimental group 2, patients received a-tDCS to the M1 and sham stimulation to the DLPFC. Lower limb motor function was assessed using the Fugl-Meyer and time up-and-go test. Assessments were made before and after 5 sessions. Results: The results indicate that following 5 sessions of a-tDCSM1-DLPFC, mobility and functional strength are better than a-tDCSM1 (P=0.04 and P=0.07). Conclusion: Dual site stimulation a-tDCSM1-DLPFC can further improve balance in patients with chronic stroke.http://cjns.gums.ac.ir/article-1-753-en.pdftranscranial direct current stimulationmotor functionstrokelower limb |
| spellingShingle | Somaye Azarnia kamran Ezzati Alia Saberi Yaser Moaddabi Babak Bakhshayesh Eghbali Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial Caspian Journal of Neurological Sciences transcranial direct current stimulation motor function stroke lower limb |
| title | Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial |
| title_full | Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial |
| title_fullStr | Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial |
| title_full_unstemmed | Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial |
| title_short | Unihemispheric Dual-site Anodal tDCS for Lower Limb Motor Function in Chronic Stroke Patients: A Randomized Clinical Trial |
| title_sort | unihemispheric dual site anodal tdcs for lower limb motor function in chronic stroke patients a randomized clinical trial |
| topic | transcranial direct current stimulation motor function stroke lower limb |
| url | http://cjns.gums.ac.ir/article-1-753-en.pdf |
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