Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

The 2.7 A crystal structure of the 55-kDa N-terminal breakage-reunion domain of topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the quinolone targets from a gram-positive bacterium, has been solved and reveals a 'closed' dimer similar in fold to Escher...

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Bibliographic Details
Main Authors: Ivan Laponogov, Dennis A Veselkov, Maninder K Sohi, Xiao-Su Pan, Aniruddha Achari, Cheng Yang, Joseph D Ferrara, L Mark Fisher, Mark R Sanderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000301&type=printable
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