The Importance of Mitochondrial DNA in Aging and Cancer
Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitoc...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/407536 |
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| _version_ | 1849304999837827072 |
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| author | Claus Desler Maiken Lise Marcker Keshav K. Singh Lene Juel Rasmussen |
| author_facet | Claus Desler Maiken Lise Marcker Keshav K. Singh Lene Juel Rasmussen |
| author_sort | Claus Desler |
| collection | DOAJ |
| description | Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides. |
| format | Article |
| id | doaj-art-408c6a5bbbbc4a4097bb9d578477b326 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-408c6a5bbbbc4a4097bb9d578477b3262025-08-20T03:55:33ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/407536407536The Importance of Mitochondrial DNA in Aging and CancerClaus Desler0Maiken Lise Marcker1Keshav K. Singh2Lene Juel Rasmussen3Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, DenmarkCenter for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, DenmarkDepartment of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USACenter for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, DenmarkMitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.http://dx.doi.org/10.4061/2011/407536 |
| spellingShingle | Claus Desler Maiken Lise Marcker Keshav K. Singh Lene Juel Rasmussen The Importance of Mitochondrial DNA in Aging and Cancer Journal of Aging Research |
| title | The Importance of Mitochondrial DNA in Aging and Cancer |
| title_full | The Importance of Mitochondrial DNA in Aging and Cancer |
| title_fullStr | The Importance of Mitochondrial DNA in Aging and Cancer |
| title_full_unstemmed | The Importance of Mitochondrial DNA in Aging and Cancer |
| title_short | The Importance of Mitochondrial DNA in Aging and Cancer |
| title_sort | importance of mitochondrial dna in aging and cancer |
| url | http://dx.doi.org/10.4061/2011/407536 |
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