Selective amino acid formulation enhances anion secretion and restores function in cystic fibrosis mutations

Selective amino acid formulation enhances anion secretion and restores function in cystic fibrosis mutations

IntroductionIn cystic fibrosis (CF), most CFTR mutations cause partial (Class II) or complete (Class I) loss of function. Modulators (VX) can improve CFTR function in Class II mutations but are ineffective for Class I mutations and may cause side effects, resulting in tolerability issues with concer...

Full description

Saved in:
Bibliographic Details
Main Authors: Astrid Grosche, Anusree Sasidharan, Matthias Salathe, Nathalie Baumlin, Damiano Angoli, Sreekala Prabhakaran, Xiaodong Xu, Sadasivan Vidyasagar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
cystic fibrosis
amino acids
human bronchial epithelial cells
chloride secretion
SLC26A9
CFTR
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1522130/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items