Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability
Topoisomerase 1 (Top1) removes transcription-associated helical stress to sup-press G4-formation and its induced recombination at genomic loci containing guanine-run containing sequences. Interestingly, Top1 binds tightly to G4 struc-tures, and its inhibition or depletion can cause elevated instabil...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2022-01-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2022a-berroyer-microbial-cell/ |
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