Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography

Diffusion tensor imaging (DTI) is considered to be a promising tool for revealing the anatomical basis of functional networks. In this study, we investigate the potential of DTI to provide the anatomical basis of paths that are used in studies of effective connectivity, using structural equation mod...

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Main Authors: Hubert M. J. Fonteijn, David G. Norris, Frans A. J. Verstraten
Format: Article
Language:English
Published: Wiley 2008-01-01
Series:International Journal of Biomedical Imaging
Online Access:http://dx.doi.org/10.1155/2008/423192
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author Hubert M. J. Fonteijn
David G. Norris
Frans A. J. Verstraten
author_facet Hubert M. J. Fonteijn
David G. Norris
Frans A. J. Verstraten
author_sort Hubert M. J. Fonteijn
collection DOAJ
description Diffusion tensor imaging (DTI) is considered to be a promising tool for revealing the anatomical basis of functional networks. In this study, we investigate the potential of DTI to provide the anatomical basis of paths that are used in studies of effective connectivity, using structural equation modeling. We have taken regions of interest from eight previously published studies, and examined the connectivity as defined by DTI-based fiber tractography between these regions. The resulting fiber tracts were then compared with the paths proposed in the original studies. For a substantial number of connections, we found fiber tracts that corresponded to the proposed paths. More importantly, we have also identified a number of cases in which tractography suggested direct connections which were not included in the original analyses. We therefore conclude that DTI-based fiber tractography can be a valuable tool to study the anatomical basis of functional networks.
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institution Kabale University
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spelling doaj-art-4080e2d388c540608095ec935face2972025-02-03T01:12:14ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962008-01-01200810.1155/2008/423192423192Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber TractographyHubert M. J. Fonteijn0David G. Norris1Frans A. J. Verstraten2Helmholtz Institute, Universiteit Utrecht, Heidelberglaan 2, 3584 CS Utrecht, The NetherlandsF.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P.O. Box 9102, 6500 HC Nijmegen, The NetherlandsHelmholtz Institute, Universiteit Utrecht, Heidelberglaan 2, 3584 CS Utrecht, The NetherlandsDiffusion tensor imaging (DTI) is considered to be a promising tool for revealing the anatomical basis of functional networks. In this study, we investigate the potential of DTI to provide the anatomical basis of paths that are used in studies of effective connectivity, using structural equation modeling. We have taken regions of interest from eight previously published studies, and examined the connectivity as defined by DTI-based fiber tractography between these regions. The resulting fiber tracts were then compared with the paths proposed in the original studies. For a substantial number of connections, we found fiber tracts that corresponded to the proposed paths. More importantly, we have also identified a number of cases in which tractography suggested direct connections which were not included in the original analyses. We therefore conclude that DTI-based fiber tractography can be a valuable tool to study the anatomical basis of functional networks.http://dx.doi.org/10.1155/2008/423192
spellingShingle Hubert M. J. Fonteijn
David G. Norris
Frans A. J. Verstraten
Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography
International Journal of Biomedical Imaging
title Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography
title_full Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography
title_fullStr Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography
title_full_unstemmed Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography
title_short Exploring the Anatomical Basis of Effective Connectivity Models with DTI-Based Fiber Tractography
title_sort exploring the anatomical basis of effective connectivity models with dti based fiber tractography
url http://dx.doi.org/10.1155/2008/423192
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