Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma
Purpose: This study explored changes in retinal microvasculature in patients with Acute Primary Angle Closure (APAC) before and after surgery, assessing their correlation with variations in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness, while also examini...
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025002248 |
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| author | Ke Yin Haomin Chen Yanxin Zhang Xinyi Li Ruihong Su Yi Yue Yingjuan Lv Lijie Dong Yi Shi Aihua Liu |
| author_facet | Ke Yin Haomin Chen Yanxin Zhang Xinyi Li Ruihong Su Yi Yue Yingjuan Lv Lijie Dong Yi Shi Aihua Liu |
| author_sort | Ke Yin |
| collection | DOAJ |
| description | Purpose: This study explored changes in retinal microvasculature in patients with Acute Primary Angle Closure (APAC) before and after surgery, assessing their correlation with variations in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness, while also examining the effects of acute intraocular pressure elevation on ocular microvasculature. Patients and methods: This was a retrospective longitudinal study that assessed 22 APAC eyes undergoing phacoemulsification, intraocular lens implantation, and trabeculectomy, along with 22 healthy fellow eyes. Optical coherence tomography angiography was used to evaluate vessel density (VD) in the optic disc and macula preoperatively, and at one week and one month postoperatively. The thicknesses of RNFL and GCIPLwere also measured. Results: Postoperatively, the superficial vascular complex (SVC) VD, including the whole image VD (wiVD) of disc and macula, continued to decrease at one month (p < 0.001, p = 0.001). In contrast, at the deep vascular complex (DVC) level, only disc wiVD showed significant changes at one month (p = 0.007). Changes in disc and macula wiVD at the SVC level were significantly correlated with changes in RNFL and GCIPL thickness (p = 0.004, p < 0.001; p = 0.018, p = 0.002), whereas VD at the DVC level was not. The SVC disc wiVD (AUROC=92.56 %) had superior diagnostic performance compared to the DVC disc wiVD (AUROC=58.06 %). Conclusions: We found acute intraocular pressure elevation has lasting effects on APAC eyes. Postoperative alterations in SVC VD seem to be more sensitive indicators for APAC patients. |
| format | Article |
| id | doaj-art-4073823d57734b79ab61de9bddcd4f9f |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-4073823d57734b79ab61de9bddcd4f9f2025-08-20T03:44:58ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410469210.1016/j.pdpdt.2025.104692Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucomaKe Yin0Haomin Chen1Yanxin Zhang2Xinyi Li3Ruihong Su4Yi Yue5Yingjuan Lv6Lijie Dong7Yi Shi8Aihua Liu9Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaCorresponding authors.; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaCorresponding authors.; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaCorresponding authors.; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukang Road, Xiqing District, Tianjin, 300384, ChinaPurpose: This study explored changes in retinal microvasculature in patients with Acute Primary Angle Closure (APAC) before and after surgery, assessing their correlation with variations in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness, while also examining the effects of acute intraocular pressure elevation on ocular microvasculature. Patients and methods: This was a retrospective longitudinal study that assessed 22 APAC eyes undergoing phacoemulsification, intraocular lens implantation, and trabeculectomy, along with 22 healthy fellow eyes. Optical coherence tomography angiography was used to evaluate vessel density (VD) in the optic disc and macula preoperatively, and at one week and one month postoperatively. The thicknesses of RNFL and GCIPLwere also measured. Results: Postoperatively, the superficial vascular complex (SVC) VD, including the whole image VD (wiVD) of disc and macula, continued to decrease at one month (p < 0.001, p = 0.001). In contrast, at the deep vascular complex (DVC) level, only disc wiVD showed significant changes at one month (p = 0.007). Changes in disc and macula wiVD at the SVC level were significantly correlated with changes in RNFL and GCIPL thickness (p = 0.004, p < 0.001; p = 0.018, p = 0.002), whereas VD at the DVC level was not. The SVC disc wiVD (AUROC=92.56 %) had superior diagnostic performance compared to the DVC disc wiVD (AUROC=58.06 %). Conclusions: We found acute intraocular pressure elevation has lasting effects on APAC eyes. Postoperative alterations in SVC VD seem to be more sensitive indicators for APAC patients.http://www.sciencedirect.com/science/article/pii/S1572100025002248Acute primary angle closureOptical coherence tomography angiographySuperficial vascular complexDeep vascular complex |
| spellingShingle | Ke Yin Haomin Chen Yanxin Zhang Xinyi Li Ruihong Su Yi Yue Yingjuan Lv Lijie Dong Yi Shi Aihua Liu Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma Photodiagnosis and Photodynamic Therapy Acute primary angle closure Optical coherence tomography angiography Superficial vascular complex Deep vascular complex |
| title | Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma |
| title_full | Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma |
| title_fullStr | Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma |
| title_full_unstemmed | Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma |
| title_short | Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma |
| title_sort | longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma |
| topic | Acute primary angle closure Optical coherence tomography angiography Superficial vascular complex Deep vascular complex |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025002248 |
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