Genetic risk factors associated with gestational diabetes in a multi-ethnic population.
<h4>Aims</h4>Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. We investigated whether the same gene loci confer a risk for gestational diabetes mellitus (GDM) in women from Hawai...
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261137&type=printable |
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| author | Paula Benny Hyeong Jun Ahn Janet Burlingame Men-Jean Lee Corrie Miller John Chen Johann Urschitz |
| author_facet | Paula Benny Hyeong Jun Ahn Janet Burlingame Men-Jean Lee Corrie Miller John Chen Johann Urschitz |
| author_sort | Paula Benny |
| collection | DOAJ |
| description | <h4>Aims</h4>Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. We investigated whether the same gene loci confer a risk for gestational diabetes mellitus (GDM) in women from Hawaii, and in particular, Pacific Islander and Filipino populations.<h4>Methods</h4>Blood was collected from 291 women with GDM and 734 matched non-diabetic controls (Pacific Islanders: 71 GDM, 197 non-diabetic controls; Filipinos: 162 GDM, 395 controls; Japanese: 58 GDM, 142 controls). Maternal DNA was used to genotype and show allele frequencies of 25 different SNPs mapped to 18 different loci.<h4>Results</h4>After adjusting for age, BMI, parity and gravidity by multivariable logistic regression, several SNPs showed significant associations with GDM and were ethnicity specific. In particular, SNPs rs1113132 (EXT2), rs1111875 (HHEX), rs2237892 (KCNQ1), rs2237895 (KCNQ1), rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM in Filipinos. For Japanese, SNPs rs4402960 (IGFBP2) and rs2237892 (KCNQ1) were significantly associated with GDM. For Pacific Islanders, SNPs rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM. Individually, none of the SNPs showed a consistent association with GDM across all three investigated ethnicities.<h4>Conclusion</h4>Several SNPs associated with T2DM are found to confer increased risk for GDM in a multiethnic cohort in Hawaii. |
| format | Article |
| id | doaj-art-407019822fd14ae587c7369d7069985e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-407019822fd14ae587c7369d7069985e2025-01-24T05:31:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026113710.1371/journal.pone.0261137Genetic risk factors associated with gestational diabetes in a multi-ethnic population.Paula BennyHyeong Jun AhnJanet BurlingameMen-Jean LeeCorrie MillerJohn ChenJohann Urschitz<h4>Aims</h4>Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. We investigated whether the same gene loci confer a risk for gestational diabetes mellitus (GDM) in women from Hawaii, and in particular, Pacific Islander and Filipino populations.<h4>Methods</h4>Blood was collected from 291 women with GDM and 734 matched non-diabetic controls (Pacific Islanders: 71 GDM, 197 non-diabetic controls; Filipinos: 162 GDM, 395 controls; Japanese: 58 GDM, 142 controls). Maternal DNA was used to genotype and show allele frequencies of 25 different SNPs mapped to 18 different loci.<h4>Results</h4>After adjusting for age, BMI, parity and gravidity by multivariable logistic regression, several SNPs showed significant associations with GDM and were ethnicity specific. In particular, SNPs rs1113132 (EXT2), rs1111875 (HHEX), rs2237892 (KCNQ1), rs2237895 (KCNQ1), rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM in Filipinos. For Japanese, SNPs rs4402960 (IGFBP2) and rs2237892 (KCNQ1) were significantly associated with GDM. For Pacific Islanders, SNPs rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM. Individually, none of the SNPs showed a consistent association with GDM across all three investigated ethnicities.<h4>Conclusion</h4>Several SNPs associated with T2DM are found to confer increased risk for GDM in a multiethnic cohort in Hawaii.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261137&type=printable |
| spellingShingle | Paula Benny Hyeong Jun Ahn Janet Burlingame Men-Jean Lee Corrie Miller John Chen Johann Urschitz Genetic risk factors associated with gestational diabetes in a multi-ethnic population. PLoS ONE |
| title | Genetic risk factors associated with gestational diabetes in a multi-ethnic population. |
| title_full | Genetic risk factors associated with gestational diabetes in a multi-ethnic population. |
| title_fullStr | Genetic risk factors associated with gestational diabetes in a multi-ethnic population. |
| title_full_unstemmed | Genetic risk factors associated with gestational diabetes in a multi-ethnic population. |
| title_short | Genetic risk factors associated with gestational diabetes in a multi-ethnic population. |
| title_sort | genetic risk factors associated with gestational diabetes in a multi ethnic population |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261137&type=printable |
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