Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions
Abstract Neuronal plasticity in the central amygdala (CeA) is essential for modulating feeding behaviors and emotional responses, potentially influencing reactions to Deoxynivalenol (DON). Acute oral administration of DON elicits a dose‐responsive reduction in food intake, accompanied by pronounced...
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| Format: | Article |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202417068 |
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| author | Liu‐Nan Yang Mingmeng Tang Andreas K. Nüssler Liegang Liu Wei Yang |
| author_facet | Liu‐Nan Yang Mingmeng Tang Andreas K. Nüssler Liegang Liu Wei Yang |
| author_sort | Liu‐Nan Yang |
| collection | DOAJ |
| description | Abstract Neuronal plasticity in the central amygdala (CeA) is essential for modulating feeding behaviors and emotional responses, potentially influencing reactions to Deoxynivalenol (DON). Acute oral administration of DON elicits a dose‐responsive reduction in food intake, accompanied by pronounced alterations in locomotor activity and feeding frequency. This study investigates circuitry adaptations that mediate DON's effects on feeding, by targeting of GABA neurons in the CeA. Following exposure to DON, an increase in connectivity between the paraventricular nucleus of the thalamus (PVT) and CeAGABA neurons is observed, suggesting the involvement of this pathway in DON's adverse effects on feeding and emotional states. Chemogenetic and optogenetic manipulations of CeAGABA neurons resulted in substantial alterations in mice's feeding and overall activity. These findings suggest that CeAGABA neurons are involved in DON‐induced anorexia and aversive‐like emotional responses. Additionally, the administration of the SCN10A antagonist (A‐803467) effectively mitigated DON‐induced anorexia and aversive‐like emotions, highlighting the pivotal role of the PVT‐CeA circuit and CeAGABA neurons in regulating the physiological and emotional impacts of DON. These findings have significant implications for public health and clinical interventions, offering potential therapeutic strategies to mitigate DON's adverse effects on human health. |
| format | Article |
| id | doaj-art-406c6f02e7134dcf95635fbd1ece3c15 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-406c6f02e7134dcf95635fbd1ece3c152025-08-20T02:18:32ZengWileyAdvanced Science2198-38442025-04-011216n/an/a10.1002/advs.202417068Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like EmotionsLiu‐Nan Yang0Mingmeng Tang1Andreas K. Nüssler2Liegang Liu3Wei Yang4Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College Huazhong University of Science and Technology Hangkong Road 13 Wuhan 430030 ChinaDepartment of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College Huazhong University of Science and Technology Hangkong Road 13 Wuhan 430030 ChinaDepartment of Traumatology BG Trauma Center University of Tübingen Schnarrenbergstr. 95 72076 Tübingen GermanyDepartment of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College Huazhong University of Science and Technology Hangkong Road 13 Wuhan 430030 ChinaDepartment of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College Huazhong University of Science and Technology Hangkong Road 13 Wuhan 430030 ChinaAbstract Neuronal plasticity in the central amygdala (CeA) is essential for modulating feeding behaviors and emotional responses, potentially influencing reactions to Deoxynivalenol (DON). Acute oral administration of DON elicits a dose‐responsive reduction in food intake, accompanied by pronounced alterations in locomotor activity and feeding frequency. This study investigates circuitry adaptations that mediate DON's effects on feeding, by targeting of GABA neurons in the CeA. Following exposure to DON, an increase in connectivity between the paraventricular nucleus of the thalamus (PVT) and CeAGABA neurons is observed, suggesting the involvement of this pathway in DON's adverse effects on feeding and emotional states. Chemogenetic and optogenetic manipulations of CeAGABA neurons resulted in substantial alterations in mice's feeding and overall activity. These findings suggest that CeAGABA neurons are involved in DON‐induced anorexia and aversive‐like emotional responses. Additionally, the administration of the SCN10A antagonist (A‐803467) effectively mitigated DON‐induced anorexia and aversive‐like emotions, highlighting the pivotal role of the PVT‐CeA circuit and CeAGABA neurons in regulating the physiological and emotional impacts of DON. These findings have significant implications for public health and clinical interventions, offering potential therapeutic strategies to mitigate DON's adverse effects on human health.https://doi.org/10.1002/advs.202417068anorexiaaversive‐like emotionscentral amygdala (CeA)deoxynivalenol (DON)paraventricular thalamus (PVT) |
| spellingShingle | Liu‐Nan Yang Mingmeng Tang Andreas K. Nüssler Liegang Liu Wei Yang Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions Advanced Science anorexia aversive‐like emotions central amygdala (CeA) deoxynivalenol (DON) paraventricular thalamus (PVT) |
| title | Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions |
| title_full | Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions |
| title_fullStr | Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions |
| title_full_unstemmed | Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions |
| title_short | Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions |
| title_sort | regulation of pvt cea circuit in deoxynivalenol induced anorexia and aversive like emotions |
| topic | anorexia aversive‐like emotions central amygdala (CeA) deoxynivalenol (DON) paraventricular thalamus (PVT) |
| url | https://doi.org/10.1002/advs.202417068 |
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