The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome
Abstract Polycystic ovary syndrome (PCOS) is an endocrine metabolic syndrome characterized by ovulation disorders, hyperandrogenemia, and polycystic ovaries, which seriously affect the psychological and physical health of childbearing women. N6-methyladenosine (m6A), as the most common mRNA epigenet...
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BMC
2025-05-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-025-01690-7 |
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| author | Leyi Jiang Jiaying Xiao Liangzhen Xie Feifei Zheng Fangliang Ge Xue Zhao Ruonan Qiang Jie Fang Zhinan Liu Zihan Xu Ran Chen Dayong Wang Yanfeng Liu Qing Xia |
| author_facet | Leyi Jiang Jiaying Xiao Liangzhen Xie Feifei Zheng Fangliang Ge Xue Zhao Ruonan Qiang Jie Fang Zhinan Liu Zihan Xu Ran Chen Dayong Wang Yanfeng Liu Qing Xia |
| author_sort | Leyi Jiang |
| collection | DOAJ |
| description | Abstract Polycystic ovary syndrome (PCOS) is an endocrine metabolic syndrome characterized by ovulation disorders, hyperandrogenemia, and polycystic ovaries, which seriously affect the psychological and physical health of childbearing women. N6-methyladenosine (m6A), as the most common mRNA epigenetic modification in eukaryotes, is vital for developing the female reproductive system and reproductive diseases. In recent years, an increasing number of studies have revealed the mechanisms by which m6A modifications and their related proteins are promoting the development of PCOS, including writers, erasers and readers. In this work, we reviewed the research progress of m6A in the pathophysiological development of PCOS from the starting point of PCOS clinical features, included the recent studies or those with significant findings related to m6A and PCOS, summarized the current commonly used therapeutic methods in PCOS and the possible targeted therapies against the m6A mechanism, and looked forward to future research directions of m6A in PCOS. With the gradual revelation of the m6A mechanism, m6A and its related proteins are expected to become a great field for PCOS treatment. |
| format | Article |
| id | doaj-art-405b6f261cd74442a01f1c7ddc90dd2e |
| institution | OA Journals |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj-art-405b6f261cd74442a01f1c7ddc90dd2e2025-08-20T02:34:07ZengBMCJournal of Ovarian Research1757-22152025-05-0118111610.1186/s13048-025-01690-7The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndromeLeyi Jiang0Jiaying Xiao1Liangzhen Xie2Feifei Zheng3Fangliang Ge4Xue Zhao5Ruonan Qiang6Jie Fang7Zhinan Liu8Zihan Xu9Ran Chen10Dayong Wang11Yanfeng Liu12Qing Xia13Department of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Harbin Medical UniversityDepartment of Gynecology, Heilongjiang University of Chinese MedicineDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Harbin Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Harbin Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Harbin Medical UniversityDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Harbin Medical UniversityDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese MedicineAbstract Polycystic ovary syndrome (PCOS) is an endocrine metabolic syndrome characterized by ovulation disorders, hyperandrogenemia, and polycystic ovaries, which seriously affect the psychological and physical health of childbearing women. N6-methyladenosine (m6A), as the most common mRNA epigenetic modification in eukaryotes, is vital for developing the female reproductive system and reproductive diseases. In recent years, an increasing number of studies have revealed the mechanisms by which m6A modifications and their related proteins are promoting the development of PCOS, including writers, erasers and readers. In this work, we reviewed the research progress of m6A in the pathophysiological development of PCOS from the starting point of PCOS clinical features, included the recent studies or those with significant findings related to m6A and PCOS, summarized the current commonly used therapeutic methods in PCOS and the possible targeted therapies against the m6A mechanism, and looked forward to future research directions of m6A in PCOS. With the gradual revelation of the m6A mechanism, m6A and its related proteins are expected to become a great field for PCOS treatment.https://doi.org/10.1186/s13048-025-01690-7Polycystic ovary syndromeN6-methyladenosineReproductive disordersChronic low-grade inflammation |
| spellingShingle | Leyi Jiang Jiaying Xiao Liangzhen Xie Feifei Zheng Fangliang Ge Xue Zhao Ruonan Qiang Jie Fang Zhinan Liu Zihan Xu Ran Chen Dayong Wang Yanfeng Liu Qing Xia The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome Journal of Ovarian Research Polycystic ovary syndrome N6-methyladenosine Reproductive disorders Chronic low-grade inflammation |
| title | The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome |
| title_full | The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome |
| title_fullStr | The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome |
| title_full_unstemmed | The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome |
| title_short | The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome |
| title_sort | emerging roles of n6 methyladenosine m6a deregulation in polycystic ovary syndrome |
| topic | Polycystic ovary syndrome N6-methyladenosine Reproductive disorders Chronic low-grade inflammation |
| url | https://doi.org/10.1186/s13048-025-01690-7 |
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