IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms

IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms

Background Pharmacological autophagy enhancement constitutes a preclinically validated strategy for preventing or treating most major age-associated diseases. Driven by this consideration, we performed a high-content/high-throughput screen on 65 000 distinct compounds on a robotized fluorescence mic...

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Main Authors: Qi Wu, Shuai Zhang, Peng Liu, Wei Xie, Guido Kroemer, Oliver Kepp, Bei Li, Pan Hui, Ai-Ling Tian, Marion Leduc, Sabrina Forveille, Peter Hamley, Warren Galloway, Liwei Zhao, Frank Madeo, Yi Tu
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/6/e002722.full
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