ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae
This study investigated bioactive compounds isolated from the mangrove endophytic fungus Actinomucor elegans AcCC18.1A for the control of Xanthomonas axonopodis pv. passiflorae (Xap), the causal agent of bacterial spot disease in passion fruit. Through classical chromatographic techniques, we isolat...
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Sociedade Brasileira de Química
2025-07-01
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| Series: | Química Nova |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000600310&lng=en&tlng=en |
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| author | Kathia Raquel Murillo Padilla Rayanne Priscila Vieira da Conceição Gisele da Costa Ramos Luana Cardoso de Oliveira José Edson de Sousa Siqueira Mayra Suelen da Silva Pinheiro Patrícia Santana Barbosa Marinho Andrey Moacir do Rosario Marinho |
| author_facet | Kathia Raquel Murillo Padilla Rayanne Priscila Vieira da Conceição Gisele da Costa Ramos Luana Cardoso de Oliveira José Edson de Sousa Siqueira Mayra Suelen da Silva Pinheiro Patrícia Santana Barbosa Marinho Andrey Moacir do Rosario Marinho |
| author_sort | Kathia Raquel Murillo Padilla |
| collection | DOAJ |
| description | This study investigated bioactive compounds isolated from the mangrove endophytic fungus Actinomucor elegans AcCC18.1A for the control of Xanthomonas axonopodis pv. passiflorae (Xap), the causal agent of bacterial spot disease in passion fruit. Through classical chromatographic techniques, we isolated four phenolic compounds: tyrosol (1), 4-hydroxyphenylacetic acid (2), 4-formylphenyl-2-phenylacetate (3), and phenylacetic acid (4), with their structures elucidated through nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). Among the isolated compounds, compound 3 was characterized as a new natural product. Antimicrobial assays were performed using the broth microdilution method against four Xap strains (Xap1-Xap4), with amoxicillin (3.9 µg mL-1) and tetracycline (3.9 µg mL-1) as positive controls. All compounds exhibited inhibitory activity, with compound 2 showing the highest efficacy (7.8 µg mL-1). These results underscore the biotechnological potential of mangrove endophytic fungi as sources of bioactive molecules against agricultural phytopathogens, offering new insights for developing sustainable strategies to control bacterial spot in passion fruit cultivation. |
| format | Article |
| id | doaj-art-4055f1a39c5d41098a0143d3177373bb |
| institution | DOAJ |
| issn | 1678-7064 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj-art-4055f1a39c5d41098a0143d3177373bb2025-08-20T02:46:58ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642025-07-0148610.21577/0100-4042.20250153ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passifloraeKathia Raquel Murillo PadillaRayanne Priscila Vieira da ConceiçãoGisele da Costa RamosLuana Cardoso de OliveiraJosé Edson de Sousa SiqueiraMayra Suelen da Silva PinheiroPatrícia Santana Barbosa Marinhohttps://orcid.org/0000-0002-9368-8574Andrey Moacir do Rosario Marinhohttps://orcid.org/0000-0002-8981-0995This study investigated bioactive compounds isolated from the mangrove endophytic fungus Actinomucor elegans AcCC18.1A for the control of Xanthomonas axonopodis pv. passiflorae (Xap), the causal agent of bacterial spot disease in passion fruit. Through classical chromatographic techniques, we isolated four phenolic compounds: tyrosol (1), 4-hydroxyphenylacetic acid (2), 4-formylphenyl-2-phenylacetate (3), and phenylacetic acid (4), with their structures elucidated through nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). Among the isolated compounds, compound 3 was characterized as a new natural product. Antimicrobial assays were performed using the broth microdilution method against four Xap strains (Xap1-Xap4), with amoxicillin (3.9 µg mL-1) and tetracycline (3.9 µg mL-1) as positive controls. All compounds exhibited inhibitory activity, with compound 2 showing the highest efficacy (7.8 µg mL-1). These results underscore the biotechnological potential of mangrove endophytic fungi as sources of bioactive molecules against agricultural phytopathogens, offering new insights for developing sustainable strategies to control bacterial spot in passion fruit cultivation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000600310&lng=en&tlng=enphenolic compoundsXanthomonaspassion fruitbacterial spotActinomucor. |
| spellingShingle | Kathia Raquel Murillo Padilla Rayanne Priscila Vieira da Conceição Gisele da Costa Ramos Luana Cardoso de Oliveira José Edson de Sousa Siqueira Mayra Suelen da Silva Pinheiro Patrícia Santana Barbosa Marinho Andrey Moacir do Rosario Marinho ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae Química Nova phenolic compounds Xanthomonas passion fruit bacterial spot Actinomucor. |
| title | ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae |
| title_full | ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae |
| title_fullStr | ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae |
| title_full_unstemmed | ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae |
| title_short | ANTIMICROBIAL ACTIVITY OF COMPOUNDS ISOLATED FROM MANGROVE-DERIVED ENDOPHYTIC FUNGUS Actinomucor elegan AGAINST Xanthomonas axonopodis pv. passiflorae |
| title_sort | antimicrobial activity of compounds isolated from mangrove derived endophytic fungus actinomucor elegan against xanthomonas axonopodis pv passiflorae |
| topic | phenolic compounds Xanthomonas passion fruit bacterial spot Actinomucor. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000600310&lng=en&tlng=en |
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