Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers
Abstract Background Hereditary breast and ovarian cancer (HBOC) syndrome is a susceptibility syndrome for cancers, such as breast and ovarian cancer, and BRCA1/2 are its causative genes. Annual breast-enhanced magnetic resonance imaging (MRI) is recommended for BRCA1/2 mutation carriers aged over 25...
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| Format: | Article |
| Language: | English |
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Japan Surgical Society
2021-10-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-021-01313-5 |
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| author | Megumi Takaoka Shozo Ohsumi Yuichiro Miyoshi Mina Takahashi Seiki Takashima Kenjiro Aogi Teruhiko Shimizu Norihiro Teramoto Yasuko Yamamoto Miki Okamura |
| author_facet | Megumi Takaoka Shozo Ohsumi Yuichiro Miyoshi Mina Takahashi Seiki Takashima Kenjiro Aogi Teruhiko Shimizu Norihiro Teramoto Yasuko Yamamoto Miki Okamura |
| author_sort | Megumi Takaoka |
| collection | DOAJ |
| description | Abstract Background Hereditary breast and ovarian cancer (HBOC) syndrome is a susceptibility syndrome for cancers, such as breast and ovarian cancer, and BRCA1/2 are its causative genes. Annual breast-enhanced magnetic resonance imaging (MRI) is recommended for BRCA1/2 mutation carriers aged over 25 years as a secondary prevention of breast cancer. However, breast MRI surveillance is rarely performed in Japan, and only four cases of breast cancer diagnosis triggered by MRI surveillance have been reported. Case presentation At our hospital, MRI triggered the diagnosis of breast cancer in four cancer-free BRCA1/2 mutation carriers. In one of our four cases, although MRI showed only a 3-mm focus, we could diagnose breast cancer by shortening the surveillance interval considering the patient’s high-risk for developing breast cancer. Conclusions Image-guided biopsy, including MRI-guided biopsy, depending on the size of the lesion, and shorter surveillance intervals are useful when there are potentially malignant findings on breast MRI surveillance for cancer-free patients with HBOC. |
| format | Article |
| id | doaj-art-40509a5bfa7a41ffac779ea0f30a4b4f |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-40509a5bfa7a41ffac779ea0f30a4b4f2025-08-20T03:16:00ZengJapan Surgical SocietySurgical Case Reports2198-77932021-10-01711510.1186/s40792-021-01313-5Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriersMegumi Takaoka0Shozo Ohsumi1Yuichiro Miyoshi2Mina Takahashi3Seiki Takashima4Kenjiro Aogi5Teruhiko Shimizu6Norihiro Teramoto7Yasuko Yamamoto8Miki Okamura9Department of Breast Oncology, National Hospital Organization Shikoku Cancer CenterDepartment of Breast Oncology, National Hospital Organization Shikoku Cancer CenterDepartment of Breast Oncology, National Hospital Organization Shikoku Cancer CenterDepartment of Breast Oncology, National Hospital Organization Shikoku Cancer CenterDepartment of Breast Oncology, National Hospital Organization Shikoku Cancer CenterDepartment of Breast Oncology, National Hospital Organization Shikoku Cancer CenterDepartment of Radiology, National Hospital Organization Shikoku Cancer CenterDepartment of Pathology, National Hospital Organization Shikoku Cancer CenterDepartment of Familial Tumor, National Hospital Organization Shikoku Cancer CenterDepartment of Familial Tumor, National Hospital Organization Shikoku Cancer CenterAbstract Background Hereditary breast and ovarian cancer (HBOC) syndrome is a susceptibility syndrome for cancers, such as breast and ovarian cancer, and BRCA1/2 are its causative genes. Annual breast-enhanced magnetic resonance imaging (MRI) is recommended for BRCA1/2 mutation carriers aged over 25 years as a secondary prevention of breast cancer. However, breast MRI surveillance is rarely performed in Japan, and only four cases of breast cancer diagnosis triggered by MRI surveillance have been reported. Case presentation At our hospital, MRI triggered the diagnosis of breast cancer in four cancer-free BRCA1/2 mutation carriers. In one of our four cases, although MRI showed only a 3-mm focus, we could diagnose breast cancer by shortening the surveillance interval considering the patient’s high-risk for developing breast cancer. Conclusions Image-guided biopsy, including MRI-guided biopsy, depending on the size of the lesion, and shorter surveillance intervals are useful when there are potentially malignant findings on breast MRI surveillance for cancer-free patients with HBOC.https://doi.org/10.1186/s40792-021-01313-5BRCAHereditary breast and ovarian cancer syndromeMRI surveillanceBreast cancer |
| spellingShingle | Megumi Takaoka Shozo Ohsumi Yuichiro Miyoshi Mina Takahashi Seiki Takashima Kenjiro Aogi Teruhiko Shimizu Norihiro Teramoto Yasuko Yamamoto Miki Okamura Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers Surgical Case Reports BRCA Hereditary breast and ovarian cancer syndrome MRI surveillance Breast cancer |
| title | Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers |
| title_full | Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers |
| title_fullStr | Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers |
| title_full_unstemmed | Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers |
| title_short | Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers |
| title_sort | four magnetic resonance imaging surveillance detected breast cancer cases in cancer free brca1 2 mutation carriers |
| topic | BRCA Hereditary breast and ovarian cancer syndrome MRI surveillance Breast cancer |
| url | https://doi.org/10.1186/s40792-021-01313-5 |
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