Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels

Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels

Abstract Kv1.3 channels in microglia are pivotal in regulating neuroinflammation. The antipsychotic chlorpromazine (CPZ) demonstrates anti-inflammatory effects by decreasing Kv1.3 activity in mPFC microglia. However, the precise mechanism of CPZ’s effect in the mPFC remains unclear, given that CPZ i...

Full description

Saved in:
Bibliographic Details
Main Authors: Seo-In Park, Soobeen Hwang, Young Lee, Hee-Yoon Lee, Soohyun Kim, Junseo Hong, Su-Hyun Jo, Se-Young Choi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Brain
Subjects:
Chlorpromazine
Kv1.3 channel
Inactivation
Microglia
Neuroinflammation
Online Access:https://doi.org/10.1186/s13041-025-01211-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items