Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation
Selenium nanoparticles (Se-NPS) are recognized for their bioavailability and low toxicity, though their inherent instability limits broader applications. This study explored the biosynthesis and functional properties of selenium nanoparticles (Se-NPS) stabilized with date pomace polysaccharides (MPS...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Food Hydrocolloids for Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025925000044 |
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| author | Gafar Babatunde Bamigbade Athira Subhash Mohammed Abdin Hebah Jarusheh Basim Abu-Jdayil Shao-Quan Liu Giovanni Palmisano Abdelmoneim Ali Afaf Kamal Eldin Mutamed Ayyash |
| author_facet | Gafar Babatunde Bamigbade Athira Subhash Mohammed Abdin Hebah Jarusheh Basim Abu-Jdayil Shao-Quan Liu Giovanni Palmisano Abdelmoneim Ali Afaf Kamal Eldin Mutamed Ayyash |
| author_sort | Gafar Babatunde Bamigbade |
| collection | DOAJ |
| description | Selenium nanoparticles (Se-NPS) are recognized for their bioavailability and low toxicity, though their inherent instability limits broader applications. This study explored the biosynthesis and functional properties of selenium nanoparticles (Se-NPS) stabilized with date pomace polysaccharides (MPS-NPS). The MPS-NPS characteristics, digestibility and impact on human gut microbiota were investigated. The MPS-NPS were well-stabilized, spherical particles averaging 65.4 nm in size, with PDI (0.032), zeta potential (–21.07 mV) and notable antioxidant activity (82.7 % DPPH, 68.9 % ABTS, 491.0 µg/mL FRAP, and 961.2 µg/mL TAC at 100 mg/L). They also showed concentration-dependent enzyme inhibition: 86.8 % α-amylase, 53.9 % α-glucosidase, and 42.4 % ACE inhibition at 100 mg/L, along with anticancer effects against Caco-2 (32.3 %) and MCF-7 (11.3 %) at 50 mg/L. MPS-NPS demonstrated broad antimicrobial activity against E. coli O 157:H7 (84.2 %), S. Typhimurium (82.5 %), S. aureus (77.2 %), and L. monocytogenes (89.24 %) and supported probiotic growth, indicating prebiotic potential. During fecal fermentation, they boosted short-chain fatty acid (SCFA) production and the abundance of SCFA-producing bacteria, including Gemmiger formicilis and Bifidobacterium species. These findings suggest MPS-NPS as a promising functional ingredient for gut health and dietary supplementation. |
| format | Article |
| id | doaj-art-404bfdc0d8dc4e26a3cc772ad12d201d |
| institution | Kabale University |
| issn | 2667-0259 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj-art-404bfdc0d8dc4e26a3cc772ad12d201d2025-01-25T04:11:28ZengElsevierFood Hydrocolloids for Health2667-02592025-06-017100198Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulationGafar Babatunde Bamigbade0Athira Subhash1Mohammed Abdin2Hebah Jarusheh3Basim Abu-Jdayil4Shao-Quan Liu5Giovanni Palmisano6Abdelmoneim Ali7Afaf Kamal Eldin8Mutamed Ayyash9Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), Al-Ain, United Arab EmiratesDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), Al-Ain, United Arab EmiratesDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), Al-Ain, United Arab EmiratesDepartment of Chemical and Petroleum Engineering, Research and Innovation on CO2 and Hydrogen (RICH), Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab EmiratesChemical and Petroleum Engineering Department, College of Engineering, United Arab Emirates University (UAEU), PO Box 15551, Al Ain, United Arab EmiratesDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, S14 Level 5, Science Drive 2 117542, SingaporeDepartment of Chemical and Petroleum Engineering, Research and Innovation on CO2 and Hydrogen (RICH), Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab EmiratesDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), Al-Ain, United Arab EmiratesDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), Al-Ain, United Arab EmiratesDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), Al-Ain, United Arab Emirates; Corresponding author.Selenium nanoparticles (Se-NPS) are recognized for their bioavailability and low toxicity, though their inherent instability limits broader applications. This study explored the biosynthesis and functional properties of selenium nanoparticles (Se-NPS) stabilized with date pomace polysaccharides (MPS-NPS). The MPS-NPS characteristics, digestibility and impact on human gut microbiota were investigated. The MPS-NPS were well-stabilized, spherical particles averaging 65.4 nm in size, with PDI (0.032), zeta potential (–21.07 mV) and notable antioxidant activity (82.7 % DPPH, 68.9 % ABTS, 491.0 µg/mL FRAP, and 961.2 µg/mL TAC at 100 mg/L). They also showed concentration-dependent enzyme inhibition: 86.8 % α-amylase, 53.9 % α-glucosidase, and 42.4 % ACE inhibition at 100 mg/L, along with anticancer effects against Caco-2 (32.3 %) and MCF-7 (11.3 %) at 50 mg/L. MPS-NPS demonstrated broad antimicrobial activity against E. coli O 157:H7 (84.2 %), S. Typhimurium (82.5 %), S. aureus (77.2 %), and L. monocytogenes (89.24 %) and supported probiotic growth, indicating prebiotic potential. During fecal fermentation, they boosted short-chain fatty acid (SCFA) production and the abundance of SCFA-producing bacteria, including Gemmiger formicilis and Bifidobacterium species. These findings suggest MPS-NPS as a promising functional ingredient for gut health and dietary supplementation.http://www.sciencedirect.com/science/article/pii/S2667025925000044Nano-seleniumMetabolomicsNanobiotechnologyGreen synthesisPolysaccharide-selenium |
| spellingShingle | Gafar Babatunde Bamigbade Athira Subhash Mohammed Abdin Hebah Jarusheh Basim Abu-Jdayil Shao-Quan Liu Giovanni Palmisano Abdelmoneim Ali Afaf Kamal Eldin Mutamed Ayyash Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation Food Hydrocolloids for Health Nano-selenium Metabolomics Nanobiotechnology Green synthesis Polysaccharide-selenium |
| title | Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation |
| title_full | Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation |
| title_fullStr | Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation |
| title_full_unstemmed | Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation |
| title_short | Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation |
| title_sort | date pomace polysaccharides capped selenium nanoparticles biosynthesis optimization physicochemical characterization biological activities stability and gut microbiota modulation |
| topic | Nano-selenium Metabolomics Nanobiotechnology Green synthesis Polysaccharide-selenium |
| url | http://www.sciencedirect.com/science/article/pii/S2667025925000044 |
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