Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America
Recent outbreaks of Oropouche virus (OROV) in Latin America demonstrate shifting epidemiological trends, with increasing clinical severity and geographic expansion driven by environmental and anthropogenic factors, many of which remain uncertain. Viral evolution with new reassortant strains, changes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/3/353 |
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| author | André Ricardo Ribas Freitas David A. Schwartz Antônio Silva Lima Neto Rosana Rodrigues Luciano Pamplona Goes Cavalcanti Pedro María Alarcón-Elbal |
| author_facet | André Ricardo Ribas Freitas David A. Schwartz Antônio Silva Lima Neto Rosana Rodrigues Luciano Pamplona Goes Cavalcanti Pedro María Alarcón-Elbal |
| author_sort | André Ricardo Ribas Freitas |
| collection | DOAJ |
| description | Recent outbreaks of Oropouche virus (OROV) in Latin America demonstrate shifting epidemiological trends, with increasing clinical severity and geographic expansion driven by environmental and anthropogenic factors, many of which remain uncertain. Viral evolution with new reassortant strains, changes in vectors, environmental degradation, and human activities have been postulated as factors that have facilitated its spread into new areas beyond the Amazon Basin. Multiple reports starting in July 2024 of pregnant women with Oropouche fever developing vertical infections and adverse perinatal outcomes, including placental infection, stillbirth, and fetal infections with microcephaly and malformation syndromes, have reinforced the public health significance of this disease. Here, we describe the evidence surrounding this re-emerging epidemic threat, examine these changes, and propose specific strategies for enhanced surveillance and a public health response. |
| format | Article |
| id | doaj-art-404b3e2003fa4a8c9d3135105f2ec1cc |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-404b3e2003fa4a8c9d3135105f2ec1cc2025-08-20T03:44:03ZengMDPI AGViruses1999-49152025-02-0117335310.3390/v17030353Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin AmericaAndré Ricardo Ribas Freitas0David A. Schwartz1Antônio Silva Lima Neto2Rosana Rodrigues3Luciano Pamplona Goes Cavalcanti4Pedro María Alarcón-Elbal5Faculdade São Leopoldo Mandic, Campinas 13045, SP, BrazilPerinatal Pathology Consulting, Atlanta, GA 30342, USACentro de Ciências da Saúde, Universidade de Fortaleza, Fortaleza 60811, CE, BrazilFaculdade São Leopoldo Mandic, Campinas 13045, SP, BrazilFaculdade de Medicina, Centro Universitário Christus, Fortaleza 60160, CE, BrazilDepartment of Animal Production and Health, Public Veterinary Health and Food Science and Technology, Faculty of Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Tirant lo Blanc 7, Alfara del Patriarca, 45115 Valencia, SpainRecent outbreaks of Oropouche virus (OROV) in Latin America demonstrate shifting epidemiological trends, with increasing clinical severity and geographic expansion driven by environmental and anthropogenic factors, many of which remain uncertain. Viral evolution with new reassortant strains, changes in vectors, environmental degradation, and human activities have been postulated as factors that have facilitated its spread into new areas beyond the Amazon Basin. Multiple reports starting in July 2024 of pregnant women with Oropouche fever developing vertical infections and adverse perinatal outcomes, including placental infection, stillbirth, and fetal infections with microcephaly and malformation syndromes, have reinforced the public health significance of this disease. Here, we describe the evidence surrounding this re-emerging epidemic threat, examine these changes, and propose specific strategies for enhanced surveillance and a public health response.https://www.mdpi.com/1999-4915/17/3/353arbovirusOropouche virusemerging zoonotic diseasebunyaviruscongenital infectionvertical transmission |
| spellingShingle | André Ricardo Ribas Freitas David A. Schwartz Antônio Silva Lima Neto Rosana Rodrigues Luciano Pamplona Goes Cavalcanti Pedro María Alarcón-Elbal Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America Viruses arbovirus Oropouche virus emerging zoonotic disease bunyavirus congenital infection vertical transmission |
| title | Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America |
| title_full | Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America |
| title_fullStr | Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America |
| title_full_unstemmed | Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America |
| title_short | Oropouche Virus (OROV): Expanding Threats, Shifting Patterns, and the Urgent Need for Collaborative Research in Latin America |
| title_sort | oropouche virus orov expanding threats shifting patterns and the urgent need for collaborative research in latin america |
| topic | arbovirus Oropouche virus emerging zoonotic disease bunyavirus congenital infection vertical transmission |
| url | https://www.mdpi.com/1999-4915/17/3/353 |
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