CIRCULATING ANTIBODIES TO ERYTHROPOIETIN ARE ASSOCIATED WITH LOWER EFFICACY OF RECOMBINANT EPOETIN TREATMENT IN PATIENTS UNDERGOING HAEMODIALYSIS

CIRCULATING ANTIBODIES TO ERYTHROPOIETIN ARE ASSOCIATED WITH LOWER EFFICACY OF RECOMBINANT EPOETIN TREATMENT IN PATIENTS UNDERGOING HAEMODIALYSIS

Biological preparations (BP) obtained by gene engineering possess a special characteristic called immunogenicity, i.e. propensity of biological drugs to induce an undesired immune response associated with arising anti-drug antibodies. These antibodies can change BP pharmacokinetics and pharmacodynam...

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Bibliographic Details
Main Authors: V. D. Nazarov, S. V. Lapin, V. A. Dobronravov, K. A. Smirnov, D. A. Mayer, T. O. Muzhetskaya, A. A. Totolian
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2018-01-01
Series:Медицинская иммунология
Subjects:
erythropoietin
anemia
immunogenicity
antibodies
Online Access:https://www.mimmun.ru/mimmun/article/view/1440
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