A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasing worldwide. Since gut-derived bacterial lipopolysaccharides (LPS) can travel via the portal vein to the liver and play an important role in producing hepatic pathology, it seemed possible that (1) LP...

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Main Authors:	Zhiyan Wang, Nore Ojogun, Yiling Liu, Lu Gan, Zeling Xiao, Jintao Feng, Wei Jiang, Yeying Chen, Benkun Zou, ChengYun Yu, Changshun Li, Asha Ashuo, Xiaobo Li, Mingsheng Fu, Jian Wu, Yiwei Chu, Robert S Munford, Mingfang Lu
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-04-01
Series:	eLife
Subjects:	metabolic dysfunction-associated steatotic liver disease acyloxyacyl hydrolase lipopolysaccharide sterol regulatory element-binding protein 1 gut–liver axis
Online Access:	https://elifesciences.org/articles/100731
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A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

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