Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects
Abstract Cancer therapy continues to face critical challenges, including drug resistance, recurrence, and severe side effects, which often compromise patient outcomes and quality of life. Exploring novel, cost-effective approaches, this review highlights the potential of Piper nigrum (black pepper)...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01716-4 |
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| author | Hesti Lina Wiraswati Ilma Fauziah Ma’ruf Nur Akmalia Hidayati Julia Ramadhanti Daniela Calina Javad Sharifi-Rad |
| author_facet | Hesti Lina Wiraswati Ilma Fauziah Ma’ruf Nur Akmalia Hidayati Julia Ramadhanti Daniela Calina Javad Sharifi-Rad |
| author_sort | Hesti Lina Wiraswati |
| collection | DOAJ |
| description | Abstract Cancer therapy continues to face critical challenges, including drug resistance, recurrence, and severe side effects, which often compromise patient outcomes and quality of life. Exploring novel, cost-effective approaches, this review highlights the potential of Piper nigrum (black pepper) extract (PNE) as a complementary anticancer agent. Piper nigrum, a widely available spice with a rich history in traditional medicine, contains bioactive compounds such as piperine, which have demonstrated significant anticancer activities including cell cycle arrest, apoptosis induction, and inhibition of tumor growth and metastasis. The review evaluates the recent findings from in vitro, in vivo, and clinical studies, emphasizing PNE's capacity to enhance the efficacy of conventional chemotherapeutic agents while mitigating their side effects. Key mechanisms underlying these effects include oxidative stress modulation, suppression of pro-metastatic factors, and synergistic interactions with established drugs like doxorubicin and paclitaxel. These interactions suggest that PNE could play a pivotal role in overcoming chemoresistance and improving therapeutic outcomes. Furthermore, this review highlights the potential benefits of PNE in resource-limited settings, where the cost of cancer treatments often restricts access. However, challenges such as compositional variability, limited bioavailability, and the need for standardization and clinical validation need to be addressed to advance the integration of PNE into basic oncology. By providing a comprehensive analysis of the anticancer mechanisms of PNE and its potential as a cost-effective adjuvant therapy, this review provides new insight into the exploitation of Piper nigrum to improve cancer treatment efficacy while reducing side effects. Future research directions are discussed to address current limitations and facilitate clinical translation. |
| format | Article |
| id | doaj-art-4046051ca79d458ab088225198cdc92c |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-4046051ca79d458ab088225198cdc92c2025-01-12T12:29:14ZengSpringerDiscover Oncology2730-60112025-01-0116112110.1007/s12672-024-01716-4Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effectsHesti Lina Wiraswati0Ilma Fauziah Ma’ruf1Nur Akmalia Hidayati2Julia Ramadhanti3Daniela Calina4Javad Sharifi-Rad5Department of Biomedical Sciences, Faculty of Medicine, Universitas PadjadjaranResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation AgencyResearch Center for Applied Microbiology, BRINDepartment of Biomedical Sciences, Faculty of Medicine, Universitas PadjadjaranDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of CraiovaUniversidad Espíritu SantoAbstract Cancer therapy continues to face critical challenges, including drug resistance, recurrence, and severe side effects, which often compromise patient outcomes and quality of life. Exploring novel, cost-effective approaches, this review highlights the potential of Piper nigrum (black pepper) extract (PNE) as a complementary anticancer agent. Piper nigrum, a widely available spice with a rich history in traditional medicine, contains bioactive compounds such as piperine, which have demonstrated significant anticancer activities including cell cycle arrest, apoptosis induction, and inhibition of tumor growth and metastasis. The review evaluates the recent findings from in vitro, in vivo, and clinical studies, emphasizing PNE's capacity to enhance the efficacy of conventional chemotherapeutic agents while mitigating their side effects. Key mechanisms underlying these effects include oxidative stress modulation, suppression of pro-metastatic factors, and synergistic interactions with established drugs like doxorubicin and paclitaxel. These interactions suggest that PNE could play a pivotal role in overcoming chemoresistance and improving therapeutic outcomes. Furthermore, this review highlights the potential benefits of PNE in resource-limited settings, where the cost of cancer treatments often restricts access. However, challenges such as compositional variability, limited bioavailability, and the need for standardization and clinical validation need to be addressed to advance the integration of PNE into basic oncology. By providing a comprehensive analysis of the anticancer mechanisms of PNE and its potential as a cost-effective adjuvant therapy, this review provides new insight into the exploitation of Piper nigrum to improve cancer treatment efficacy while reducing side effects. Future research directions are discussed to address current limitations and facilitate clinical translation.https://doi.org/10.1007/s12672-024-01716-4AnticancerApoptosisBlack pepperChemotherapyPiper nigrumSynergistic therapy |
| spellingShingle | Hesti Lina Wiraswati Ilma Fauziah Ma’ruf Nur Akmalia Hidayati Julia Ramadhanti Daniela Calina Javad Sharifi-Rad Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects Discover Oncology Anticancer Apoptosis Black pepper Chemotherapy Piper nigrum Synergistic therapy |
| title | Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects |
| title_full | Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects |
| title_fullStr | Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects |
| title_full_unstemmed | Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects |
| title_short | Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects |
| title_sort | harnessing the anticancer potential of piper nigrum a synergistic approach to chemotherapy enhancement and reduced side effects |
| topic | Anticancer Apoptosis Black pepper Chemotherapy Piper nigrum Synergistic therapy |
| url | https://doi.org/10.1007/s12672-024-01716-4 |
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