Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S053155652500110X |
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| author | Dongfeng Lan Dan Zhang Xiaofang Dai Ji Cai He Zhou Tao Song Xianyao Wang Qinghong Kong Zhengzhen Tang Jun Tan Jidong Zhang |
| author_facet | Dongfeng Lan Dan Zhang Xiaofang Dai Ji Cai He Zhou Tao Song Xianyao Wang Qinghong Kong Zhengzhen Tang Jun Tan Jidong Zhang |
| author_sort | Dongfeng Lan |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular differentiation. Exosomes (Exos), a type of extracellular vesicles (EVs) secreted by MSCs via the paracrine pathway, play a pivotal role in conveying the biological functions of MSCs. Accumulating evidence from extensive research underscores the remarkable anti-aging potential of both MSCs and their Exos. This review comprehensively explores the impact of MSCs and their Exos on key hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Furthermore, this paper highlights emerging strategies and novel approaches for modulating the aging process, offering insights into potential therapeutic interventions. |
| format | Article |
| id | doaj-art-40459f27c7b54239b45bbcdcf7ce28fa |
| institution | OA Journals |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-40459f27c7b54239b45bbcdcf7ce28fa2025-08-20T02:34:53ZengElsevierExperimental Gerontology1873-68152025-07-0120611278110.1016/j.exger.2025.112781Mesenchymal stem cells and exosomes: A novel therapeutic approach for agingDongfeng Lan0Dan Zhang1Xiaofang Dai2Ji Cai3He Zhou4Tao Song5Xianyao Wang6Qinghong Kong7Zhengzhen Tang8Jun Tan9Jidong Zhang10Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaZunyi Medical University Library, Zunyi 563000, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaGuizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Pediatrics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi 563000, China; Corresponding authors.Department of Histology and Embryology, Zunyi Medical University, Zunyi 563000, China; Corresponding authors.Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China; Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi 563000, China; Correspondence to: J. Zhang, Department of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province 563000, China.Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular differentiation. Exosomes (Exos), a type of extracellular vesicles (EVs) secreted by MSCs via the paracrine pathway, play a pivotal role in conveying the biological functions of MSCs. Accumulating evidence from extensive research underscores the remarkable anti-aging potential of both MSCs and their Exos. This review comprehensively explores the impact of MSCs and their Exos on key hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Furthermore, this paper highlights emerging strategies and novel approaches for modulating the aging process, offering insights into potential therapeutic interventions.http://www.sciencedirect.com/science/article/pii/S053155652500110XMesenchymal stem cellsExosomesAging |
| spellingShingle | Dongfeng Lan Dan Zhang Xiaofang Dai Ji Cai He Zhou Tao Song Xianyao Wang Qinghong Kong Zhengzhen Tang Jun Tan Jidong Zhang Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging Experimental Gerontology Mesenchymal stem cells Exosomes Aging |
| title | Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging |
| title_full | Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging |
| title_fullStr | Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging |
| title_full_unstemmed | Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging |
| title_short | Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging |
| title_sort | mesenchymal stem cells and exosomes a novel therapeutic approach for aging |
| topic | Mesenchymal stem cells Exosomes Aging |
| url | http://www.sciencedirect.com/science/article/pii/S053155652500110X |
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