Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.

Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.

Inhibitory killer cell immunoglobulin-like receptors (iKIRs) are a family of inhibitory receptors that are expressed by natural killer (NK) cells and late-stage differentiated T cells. There is accumulating evidence that iKIRs regulate T cell-mediated immunity. Recently, we reported that T cell-medi...

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Main Authors: Laura Mora-Bitria, Bisrat J Debebe, Kelly L Miners, Kristin Ladell, Charandeep Kaur, James A Traherne, Wei Jiang, David A Price, Linda Hadcocks, Nicholas A R McQuibban, John Trowsdale, F Susan Wong, Nikolas Pontikos, Christoph Niederalt, Becca Asquith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011456
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