Social Cognition in Patients with Early-Onset Parkinson’s Disease
Social cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial em...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2021/8852087 |
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| author | Ana Natalia Seubert-Ravelo Ma Guillermina Yáñez-Téllez María Lizbeth Lazo-Barriga Alejandra Calderón Vallejo Carlos Eduardo Martínez-Cortés Adela Hernández-Galván |
| author_facet | Ana Natalia Seubert-Ravelo Ma Guillermina Yáñez-Téllez María Lizbeth Lazo-Barriga Alejandra Calderón Vallejo Carlos Eduardo Martínez-Cortés Adela Hernández-Galván |
| author_sort | Ana Natalia Seubert-Ravelo |
| collection | DOAJ |
| description | Social cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial emotion, theory of mind (ToM), and decision-making domains, with limited research reporting on social reasoning. The main objective of this work was to compare SC ability across four domains: emotional processing, social reasoning, ToM, and decision-making between patients with EOPD and healthy controls. Twenty-five nondemented patients with EOPD and 25 controls matched for sex, age, and educational level were enrolled. A battery that included six SC tests was administered to all study participants; a decision-making scale was completed by participants’ partners. Statistically significant differences were found between patients with EOPD and controls in all subtests across the four SC domains studied. The EOPD group demonstrated worse performance on all tasks, with large effect sizes. Differences remained significant after adjusting for Montreal Cognitive Assessment (MoCA) test scores for all SC subtests except the decision-making scale and the Iowa gambling task. No significant correlations between SC and other clinical PD variables were found. Our study shows that patients with EOPD perform significantly below controls in multiple SC domains affecting recognition of facial emotion, social reasoning, ToM, and decision-making. Only decision-making seems to be mediated by overall cognitive ability. The confounding or contributing effect of other clinical PD variables should be studied further. |
| format | Article |
| id | doaj-art-40437c1d839544e281f444a9711b85eb |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-40437c1d839544e281f444a9711b85eb2025-02-03T05:49:26ZengWileyParkinson's Disease2090-80832042-00802021-01-01202110.1155/2021/88520878852087Social Cognition in Patients with Early-Onset Parkinson’s DiseaseAna Natalia Seubert-Ravelo0Ma Guillermina Yáñez-Téllez1María Lizbeth Lazo-Barriga2Alejandra Calderón Vallejo3Carlos Eduardo Martínez-Cortés4Adela Hernández-Galván5Neuroscience Department, Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, México City, MexicoNeuroscience Department, Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, México City, MexicoNeuroscience Department, Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, México City, MexicoServicio de Neurología, Hospital de Especialidades Centro Médico Nacional Siglo XXI, México City, MexicoServicio de Neurología, Hospital de Especialidades Centro Médico Nacional Siglo XXI, México City, MexicoCentro de Investigación Transdisciplinar en Psicología, Universidad Autónoma del Estado de Morelos, Cuernavaca, MexicoSocial cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial emotion, theory of mind (ToM), and decision-making domains, with limited research reporting on social reasoning. The main objective of this work was to compare SC ability across four domains: emotional processing, social reasoning, ToM, and decision-making between patients with EOPD and healthy controls. Twenty-five nondemented patients with EOPD and 25 controls matched for sex, age, and educational level were enrolled. A battery that included six SC tests was administered to all study participants; a decision-making scale was completed by participants’ partners. Statistically significant differences were found between patients with EOPD and controls in all subtests across the four SC domains studied. The EOPD group demonstrated worse performance on all tasks, with large effect sizes. Differences remained significant after adjusting for Montreal Cognitive Assessment (MoCA) test scores for all SC subtests except the decision-making scale and the Iowa gambling task. No significant correlations between SC and other clinical PD variables were found. Our study shows that patients with EOPD perform significantly below controls in multiple SC domains affecting recognition of facial emotion, social reasoning, ToM, and decision-making. Only decision-making seems to be mediated by overall cognitive ability. The confounding or contributing effect of other clinical PD variables should be studied further.http://dx.doi.org/10.1155/2021/8852087 |
| spellingShingle | Ana Natalia Seubert-Ravelo Ma Guillermina Yáñez-Téllez María Lizbeth Lazo-Barriga Alejandra Calderón Vallejo Carlos Eduardo Martínez-Cortés Adela Hernández-Galván Social Cognition in Patients with Early-Onset Parkinson’s Disease Parkinson's Disease |
| title | Social Cognition in Patients with Early-Onset Parkinson’s Disease |
| title_full | Social Cognition in Patients with Early-Onset Parkinson’s Disease |
| title_fullStr | Social Cognition in Patients with Early-Onset Parkinson’s Disease |
| title_full_unstemmed | Social Cognition in Patients with Early-Onset Parkinson’s Disease |
| title_short | Social Cognition in Patients with Early-Onset Parkinson’s Disease |
| title_sort | social cognition in patients with early onset parkinson s disease |
| url | http://dx.doi.org/10.1155/2021/8852087 |
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