Co-circulation and persistence of multiple A/H3N2 influenza variants in China
The spread of influenza A/H3N2 variants possessing the hemagglutinin 121 K mutation and the unexpectedly high incidence of influenza in the 2017–2018 northern hemisphere influenza season have raised serious concerns about the next pandemic. We summarized the national surveillance data of seasonal in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1648183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850265922933096448 |
|---|---|
| author | Weifeng Shi Changwen Ke Shisong Fang Juan Li Hao Song Xiyan Li Tao Hu Jie Wu Tao Chen Lina Yi Yingchao Song Xin Wang Weijia Xing Weijuan Huang Hong Xiao Lijun Liang Bo Peng Weihua Wu Hui Liu William J. Liu Edward C. Holmes George F. Gao Dayan Wang |
| author_facet | Weifeng Shi Changwen Ke Shisong Fang Juan Li Hao Song Xiyan Li Tao Hu Jie Wu Tao Chen Lina Yi Yingchao Song Xin Wang Weijia Xing Weijuan Huang Hong Xiao Lijun Liang Bo Peng Weihua Wu Hui Liu William J. Liu Edward C. Holmes George F. Gao Dayan Wang |
| author_sort | Weifeng Shi |
| collection | DOAJ |
| description | The spread of influenza A/H3N2 variants possessing the hemagglutinin 121 K mutation and the unexpectedly high incidence of influenza in the 2017–2018 northern hemisphere influenza season have raised serious concerns about the next pandemic. We summarized the national surveillance data of seasonal influenza in China and identified marked differences in influenza epidemics between northern and southern China, particularly the predominating subtype and the presence of an additional summer peak in southern China. Notably, a minor spring peak of influenza caused by a different virus subtype was also observed. We also revealed that the 3C.2a lineage was dominant from the summer of 2015 to the end of the 2015–2016 peak season in China, after which the 3C.2a2 lineage predominated despite the importation and co-circulation of the 121 K variants of 3C.2a1 and 3C.2a3 lineages at the global level. Finally, an analysis based on genetic distances revealed a delay in A/H3N2 vaccine strain update. Overall, our results highlight the complicated circulation pattern of seasonal influenza in China and the necessity for a timely vaccine strain update worldwide. |
| format | Article |
| id | doaj-art-4041d72581074b4bbf728a951e0bbf84 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-4041d72581074b4bbf728a951e0bbf842025-08-20T01:54:18ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811157116710.1080/22221751.2019.1648183Co-circulation and persistence of multiple A/H3N2 influenza variants in ChinaWeifeng Shi0Changwen Ke1Shisong Fang2Juan Li3Hao Song4Xiyan Li5Tao Hu6Jie Wu7Tao Chen8Lina Yi9Yingchao Song10Xin Wang11Weijia Xing12Weijuan Huang13Hong Xiao14Lijun Liang15Bo Peng16Weihua Wu17Hui Liu18William J. Liu19Edward C. Holmes20George F. Gao21Dayan Wang22Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of ChinaDivision of Microbiology Test, Shenzhen Centre for Disease Control and Prevention, Shenzhen, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaChinese Academy of Sciences, Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Beijing, People’s Republic of ChinaChinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of ChinaChinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of ChinaDivision of Microbiology Test, Shenzhen Centre for Disease Control and Prevention, Shenzhen, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaChinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of ChinaDivision of Microbiology Test, Shenzhen Centre for Disease Control and Prevention, Shenzhen, People’s Republic of ChinaDivision of Microbiology Test, Shenzhen Centre for Disease Control and Prevention, Shenzhen, People’s Republic of ChinaDivision of Microbiology Test, Shenzhen Centre for Disease Control and Prevention, Shenzhen, People’s Republic of ChinaChinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, AustraliaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaChinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaThe spread of influenza A/H3N2 variants possessing the hemagglutinin 121 K mutation and the unexpectedly high incidence of influenza in the 2017–2018 northern hemisphere influenza season have raised serious concerns about the next pandemic. We summarized the national surveillance data of seasonal influenza in China and identified marked differences in influenza epidemics between northern and southern China, particularly the predominating subtype and the presence of an additional summer peak in southern China. Notably, a minor spring peak of influenza caused by a different virus subtype was also observed. We also revealed that the 3C.2a lineage was dominant from the summer of 2015 to the end of the 2015–2016 peak season in China, after which the 3C.2a2 lineage predominated despite the importation and co-circulation of the 121 K variants of 3C.2a1 and 3C.2a3 lineages at the global level. Finally, an analysis based on genetic distances revealed a delay in A/H3N2 vaccine strain update. Overall, our results highlight the complicated circulation pattern of seasonal influenza in China and the necessity for a timely vaccine strain update worldwide.https://www.tandfonline.com/doi/10.1080/22221751.2019.1648183Influenza virusA/H3N2vaccinemutation |
| spellingShingle | Weifeng Shi Changwen Ke Shisong Fang Juan Li Hao Song Xiyan Li Tao Hu Jie Wu Tao Chen Lina Yi Yingchao Song Xin Wang Weijia Xing Weijuan Huang Hong Xiao Lijun Liang Bo Peng Weihua Wu Hui Liu William J. Liu Edward C. Holmes George F. Gao Dayan Wang Co-circulation and persistence of multiple A/H3N2 influenza variants in China Emerging Microbes and Infections Influenza virus A/H3N2 vaccine mutation |
| title | Co-circulation and persistence of multiple A/H3N2 influenza variants in China |
| title_full | Co-circulation and persistence of multiple A/H3N2 influenza variants in China |
| title_fullStr | Co-circulation and persistence of multiple A/H3N2 influenza variants in China |
| title_full_unstemmed | Co-circulation and persistence of multiple A/H3N2 influenza variants in China |
| title_short | Co-circulation and persistence of multiple A/H3N2 influenza variants in China |
| title_sort | co circulation and persistence of multiple a h3n2 influenza variants in china |
| topic | Influenza virus A/H3N2 vaccine mutation |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1648183 |
| work_keys_str_mv | AT weifengshi cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT changwenke cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT shisongfang cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT juanli cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT haosong cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT xiyanli cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT taohu cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT jiewu cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT taochen cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT linayi cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT yingchaosong cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT xinwang cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT weijiaxing cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT weijuanhuang cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT hongxiao cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT lijunliang cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT bopeng cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT weihuawu cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT huiliu cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT williamjliu cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT edwardcholmes cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT georgefgao cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina AT dayanwang cocirculationandpersistenceofmultipleah3n2influenzavariantsinchina |