Tailored Therapeutic Approach in a Patient With Diffuse Large B‐Cell Lymphoma With Meningeal Infiltration, Concurrent Classic Hodgkin Lymphoma, and Smoldering Multiple Myeloma: A Case Report

ABSTRACT Background Coexisting primary hematologic malignancies in untreated multiple myeloma (MM) are rare. Case A 69‐year‐old man with smoldering multiple myeloma (sMM) presented with lymphadenopathies and an intracranial mass. He was diagnosed with diffuse large B‐cell lymphoma (DLBCL), classic H...

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Main Authors: Giusy Ceparano, Daniele Lorenzini, Maurilio Ponzoni, Giorgia Levati, Davide Epifania, Vincenzo Marasco
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Cancer Reports
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Online Access:https://doi.org/10.1002/cnr2.70102
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Summary:ABSTRACT Background Coexisting primary hematologic malignancies in untreated multiple myeloma (MM) are rare. Case A 69‐year‐old man with smoldering multiple myeloma (sMM) presented with lymphadenopathies and an intracranial mass. He was diagnosed with diffuse large B‐cell lymphoma (DLBCL), classic Hodgkin lymphoma (cHL), and sMM. The patient received R‐CHOP and R‐ICE, followed by autologous stem cell transplantation, achieving complete remission of DLBCL and cHL, and very good partial remission of MM. Conclusion This case illustrates the complexity of managing multiple malignancies and the importance of a tailored therapeutic approach.
ISSN:2573-8348