Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
Atherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also par...
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Wiley
2017-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2017/8135934 |
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author | Di Wang Zhiyan Wang Lili Zhang Yi Wang |
author_facet | Di Wang Zhiyan Wang Lili Zhang Yi Wang |
author_sort | Di Wang |
collection | DOAJ |
description | Atherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also participate all in the inflammatory response of atherosclerosis via multiple intricate pathways. For instance, endothelial dysfunction has historically been considered to be the initiator of the development of atherosclerosis. The migration and proliferation of smooth muscle cells also play a pivotal role in the progression of atherosclerosis. Additionally, the fibroblasts from the adventitia and adipocytes from perivascular adipose tissue have received considerable attention given their special functions that contribute to atherosclerosis. In addition, numerous types of cytokines produced by different cells from the arterial vessel wall, including endothelium-derived relaxing factors, endothelium-derived contracting factors, tumor necrosis factors, interleukin, adhesion molecules, interferon, and adventitium-derived relaxing factors, have been implicated in atherosclerosis. Herein, we summarize the possible roles of different cells from the entire arterial vessel wall in the pathogenesis of atherosclerosis. |
format | Article |
id | doaj-art-402d6c0ffaa847d682676ea769078db2 |
institution | Kabale University |
issn | 0962-9351 1466-1861 |
language | English |
publishDate | 2017-01-01 |
publisher | Wiley |
record_format | Article |
series | Mediators of Inflammation |
spelling | doaj-art-402d6c0ffaa847d682676ea769078db22025-02-03T01:03:37ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/81359348135934Roles of Cells from the Arterial Vessel Wall in AtherosclerosisDi Wang0Zhiyan Wang1Lili Zhang2Yi Wang3Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaAtherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also participate all in the inflammatory response of atherosclerosis via multiple intricate pathways. For instance, endothelial dysfunction has historically been considered to be the initiator of the development of atherosclerosis. The migration and proliferation of smooth muscle cells also play a pivotal role in the progression of atherosclerosis. Additionally, the fibroblasts from the adventitia and adipocytes from perivascular adipose tissue have received considerable attention given their special functions that contribute to atherosclerosis. In addition, numerous types of cytokines produced by different cells from the arterial vessel wall, including endothelium-derived relaxing factors, endothelium-derived contracting factors, tumor necrosis factors, interleukin, adhesion molecules, interferon, and adventitium-derived relaxing factors, have been implicated in atherosclerosis. Herein, we summarize the possible roles of different cells from the entire arterial vessel wall in the pathogenesis of atherosclerosis.http://dx.doi.org/10.1155/2017/8135934 |
spellingShingle | Di Wang Zhiyan Wang Lili Zhang Yi Wang Roles of Cells from the Arterial Vessel Wall in Atherosclerosis Mediators of Inflammation |
title | Roles of Cells from the Arterial Vessel Wall in Atherosclerosis |
title_full | Roles of Cells from the Arterial Vessel Wall in Atherosclerosis |
title_fullStr | Roles of Cells from the Arterial Vessel Wall in Atherosclerosis |
title_full_unstemmed | Roles of Cells from the Arterial Vessel Wall in Atherosclerosis |
title_short | Roles of Cells from the Arterial Vessel Wall in Atherosclerosis |
title_sort | roles of cells from the arterial vessel wall in atherosclerosis |
url | http://dx.doi.org/10.1155/2017/8135934 |
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