Roles of Cells from the Arterial Vessel Wall in Atherosclerosis

Atherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also par...

Full description

Saved in:
Bibliographic Details
Main Authors: Di Wang, Zhiyan Wang, Lili Zhang, Yi Wang
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/8135934
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832566606647001088
author Di Wang
Zhiyan Wang
Lili Zhang
Yi Wang
author_facet Di Wang
Zhiyan Wang
Lili Zhang
Yi Wang
author_sort Di Wang
collection DOAJ
description Atherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also participate all in the inflammatory response of atherosclerosis via multiple intricate pathways. For instance, endothelial dysfunction has historically been considered to be the initiator of the development of atherosclerosis. The migration and proliferation of smooth muscle cells also play a pivotal role in the progression of atherosclerosis. Additionally, the fibroblasts from the adventitia and adipocytes from perivascular adipose tissue have received considerable attention given their special functions that contribute to atherosclerosis. In addition, numerous types of cytokines produced by different cells from the arterial vessel wall, including endothelium-derived relaxing factors, endothelium-derived contracting factors, tumor necrosis factors, interleukin, adhesion molecules, interferon, and adventitium-derived relaxing factors, have been implicated in atherosclerosis. Herein, we summarize the possible roles of different cells from the entire arterial vessel wall in the pathogenesis of atherosclerosis.
format Article
id doaj-art-402d6c0ffaa847d682676ea769078db2
institution Kabale University
issn 0962-9351
1466-1861
language English
publishDate 2017-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-402d6c0ffaa847d682676ea769078db22025-02-03T01:03:37ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/81359348135934Roles of Cells from the Arterial Vessel Wall in AtherosclerosisDi Wang0Zhiyan Wang1Lili Zhang2Yi Wang3Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaAtherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also participate all in the inflammatory response of atherosclerosis via multiple intricate pathways. For instance, endothelial dysfunction has historically been considered to be the initiator of the development of atherosclerosis. The migration and proliferation of smooth muscle cells also play a pivotal role in the progression of atherosclerosis. Additionally, the fibroblasts from the adventitia and adipocytes from perivascular adipose tissue have received considerable attention given their special functions that contribute to atherosclerosis. In addition, numerous types of cytokines produced by different cells from the arterial vessel wall, including endothelium-derived relaxing factors, endothelium-derived contracting factors, tumor necrosis factors, interleukin, adhesion molecules, interferon, and adventitium-derived relaxing factors, have been implicated in atherosclerosis. Herein, we summarize the possible roles of different cells from the entire arterial vessel wall in the pathogenesis of atherosclerosis.http://dx.doi.org/10.1155/2017/8135934
spellingShingle Di Wang
Zhiyan Wang
Lili Zhang
Yi Wang
Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
Mediators of Inflammation
title Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
title_full Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
title_fullStr Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
title_full_unstemmed Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
title_short Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
title_sort roles of cells from the arterial vessel wall in atherosclerosis
url http://dx.doi.org/10.1155/2017/8135934
work_keys_str_mv AT diwang rolesofcellsfromthearterialvesselwallinatherosclerosis
AT zhiyanwang rolesofcellsfromthearterialvesselwallinatherosclerosis
AT lilizhang rolesofcellsfromthearterialvesselwallinatherosclerosis
AT yiwang rolesofcellsfromthearterialvesselwallinatherosclerosis