Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease
Chronic kidney disease (CKD) is one kind of illness with abnormal renal structure and function caused by many factors. Probiotics can be used to regulate intestinal microflora and enhance intestinal mucosal barrier, thus, intervention with probiotics may be regarded as one of the potential ways to p...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2025-01-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037740354142208 |
|---|---|
| author | Weitao Geng Dehua Wang Jiangye He Xinyuan Li Longgang Jia Yanping Wang |
| author_facet | Weitao Geng Dehua Wang Jiangye He Xinyuan Li Longgang Jia Yanping Wang |
| author_sort | Weitao Geng |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is one kind of illness with abnormal renal structure and function caused by many factors. Probiotics can be used to regulate intestinal microflora and enhance intestinal mucosal barrier, thus, intervention with probiotics may be regarded as one of the potential ways to protect against CKD. In vitro and in vivo experiments showed that Lactiplantibacillus plantarum MA2 (MA2), a probiotic separated from traditional Chinese Tibetan kefir grains, could degrade the uremic toxins including creatinine, urea nitrogen and uric acid. Oral administration of MA2 or its inactive strains (IMA2) could decrease serum uremic toxins of adenine-induced CKD mice, and also elevate the relative expression of claudin-1. Meanwhile, intervention of MA2 or IMA2 decreased the contents of lipopolysaccharide, Toll-like receptor 4 (TLR4) and interleukin-1β (IL-1β) in the kidney. 16S rDNA sequencing results indicated that the intervention of MA2 or IMA2 regulated the gut microbiota structure by elevating the abundance of Lactobacillus, and decreasing the abundance of Proteobacteria. Thus, oral administration of MA2 or IMA2 can reduce the uremic toxins in CKD mice by regulating gut microflora and restoring the intestinal mucosal barrier. Our study provided a theoretical basis for the application of MA2 and its postbiotics in the CKD intervention and treatment. |
| format | Article |
| id | doaj-art-402a2fe175a04074880d2e1d57e313a8 |
| institution | DOAJ |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-402a2fe175a04074880d2e1d57e313a82025-08-20T02:56:47ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-01-01141925001910.26599/FSHW.2024.9250019Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney diseaseWeitao Geng0Dehua Wang1Jiangye He2Xinyuan Li3Longgang Jia4Yanping Wang5College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, ChinaCollege of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, ChinaCollege of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, ChinaCollege of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, ChinaCollege of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, ChinaCollege of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, ChinaChronic kidney disease (CKD) is one kind of illness with abnormal renal structure and function caused by many factors. Probiotics can be used to regulate intestinal microflora and enhance intestinal mucosal barrier, thus, intervention with probiotics may be regarded as one of the potential ways to protect against CKD. In vitro and in vivo experiments showed that Lactiplantibacillus plantarum MA2 (MA2), a probiotic separated from traditional Chinese Tibetan kefir grains, could degrade the uremic toxins including creatinine, urea nitrogen and uric acid. Oral administration of MA2 or its inactive strains (IMA2) could decrease serum uremic toxins of adenine-induced CKD mice, and also elevate the relative expression of claudin-1. Meanwhile, intervention of MA2 or IMA2 decreased the contents of lipopolysaccharide, Toll-like receptor 4 (TLR4) and interleukin-1β (IL-1β) in the kidney. 16S rDNA sequencing results indicated that the intervention of MA2 or IMA2 regulated the gut microbiota structure by elevating the abundance of Lactobacillus, and decreasing the abundance of Proteobacteria. Thus, oral administration of MA2 or IMA2 can reduce the uremic toxins in CKD mice by regulating gut microflora and restoring the intestinal mucosal barrier. Our study provided a theoretical basis for the application of MA2 and its postbiotics in the CKD intervention and treatment.https://www.sciopen.com/article/10.26599/FSHW.2024.9250019chronic kidney diseaselactiplantibacillus plantarumpostbioticuremic toxingut microbiota |
| spellingShingle | Weitao Geng Dehua Wang Jiangye He Xinyuan Li Longgang Jia Yanping Wang Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease Food Science and Human Wellness chronic kidney disease lactiplantibacillus plantarum postbiotic uremic toxin gut microbiota |
| title | Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease |
| title_full | Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease |
| title_fullStr | Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease |
| title_full_unstemmed | Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease |
| title_short | Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease |
| title_sort | modulatory effects of lactiplantibacillus plantarum ma2 and its postbiotic on the adenine induced chronic kidney disease |
| topic | chronic kidney disease lactiplantibacillus plantarum postbiotic uremic toxin gut microbiota |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250019 |
| work_keys_str_mv | AT weitaogeng modulatoryeffectsoflactiplantibacillusplantarumma2anditspostbioticontheadenineinducedchronickidneydisease AT dehuawang modulatoryeffectsoflactiplantibacillusplantarumma2anditspostbioticontheadenineinducedchronickidneydisease AT jiangyehe modulatoryeffectsoflactiplantibacillusplantarumma2anditspostbioticontheadenineinducedchronickidneydisease AT xinyuanli modulatoryeffectsoflactiplantibacillusplantarumma2anditspostbioticontheadenineinducedchronickidneydisease AT longgangjia modulatoryeffectsoflactiplantibacillusplantarumma2anditspostbioticontheadenineinducedchronickidneydisease AT yanpingwang modulatoryeffectsoflactiplantibacillusplantarumma2anditspostbioticontheadenineinducedchronickidneydisease |