The injury effect of osteopontin in sepsis-associated lung injury

The injury effect of osteopontin in sepsis-associated lung injury

Abstract Background Sepsis is a severe condition causing organ failure due to an abnormal immune reaction to infection, characterized by ongoing excessive inflammation and immune system issues. Osteopontin (OPN) is secreted by various cells and plays a crucial role in inflammatory responses and immu...

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Bibliographic Details
Main Authors: Qian Wang, Zhicai Yu, Zhixin Song, Xue Lu, Zhu Li, Dandan Pi, Jing Li, Feng Xu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Inflammation
Subjects:
Sepsis
Lung injure
Osteopontin
Macrophage pyroptosis
Online Access:https://doi.org/10.1186/s12950-025-00430-4
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