Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade
The aim of this study was to investigate the effects of ethanolic extract of Pueraria tuberosa (PT) on sexual behaviour and androgenic activity. Male albino rats were divided into four groups of six animals each: control group 1 (2% acacia solution), PT-treated group 2 (50 mg/Kg), PT-treated group 3...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/780659 |
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| author | Nagendra Singh Chauhan Vikas Sharma Mayank Thakur Alexandra Christine Helena Frankland Sawaya V. K. Dixit |
| author_facet | Nagendra Singh Chauhan Vikas Sharma Mayank Thakur Alexandra Christine Helena Frankland Sawaya V. K. Dixit |
| author_sort | Nagendra Singh Chauhan |
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| description | The aim of this study was to investigate the effects of ethanolic extract of Pueraria tuberosa (PT) on sexual behaviour and androgenic activity. Male albino rats were divided into four groups of six animals each: control group 1 (2% acacia solution), PT-treated group 2 (50 mg/Kg), PT-treated group 3 (100 mg/Kg), and PT-treated group 4 (150 mg/Kg). Sexual behavior of male rats in the presence of a female rat was recorded. The treated groups were evaluated for sexual parameters. The extract was characterized using LC-MS. The effect of treatment on anabolic and weight of secondary sexual organs was determined. The histological changes in section of testis and epididymis after treatment were observed. Sperm count in epididymis and fructose content in seminal vesicles were also measured. Levels of hormones like FSH, LH, and T were determined. A dose-dependent increase in sexual behaviors was evidenced in the animals of extract treated groups. Increase in testis weight was recorded in PT. At the highest dose PT also affects the hormones level. The four compounds namely puerarin, daidzein, biochanin-A and formononetin were identified in ethanolic extract using LC-MS. It concluded that PT extract possesses androgenic effect and it significantly increased the sexual behaviour and hormones level. |
| format | Article |
| id | doaj-art-4028842fae874771b7337d4bbb84c16c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4028842fae874771b7337d4bbb84c16c2025-02-03T05:50:16ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/780659780659Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH CascadeNagendra Singh Chauhan0Vikas Sharma1Mayank Thakur2Alexandra Christine Helena Frankland Sawaya3V. K. Dixit4Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, Madhya Pradesh 470003, IndiaDepartment of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, Madhya Pradesh 470003, IndiaCentral Institute for Laboratory Medicine, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, GermanyDepartment of Plant Biology, Institute of Biology, State University of Campinas, Campinas, SP 13083-970, BrazilDepartment of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, Madhya Pradesh 470003, IndiaThe aim of this study was to investigate the effects of ethanolic extract of Pueraria tuberosa (PT) on sexual behaviour and androgenic activity. Male albino rats were divided into four groups of six animals each: control group 1 (2% acacia solution), PT-treated group 2 (50 mg/Kg), PT-treated group 3 (100 mg/Kg), and PT-treated group 4 (150 mg/Kg). Sexual behavior of male rats in the presence of a female rat was recorded. The treated groups were evaluated for sexual parameters. The extract was characterized using LC-MS. The effect of treatment on anabolic and weight of secondary sexual organs was determined. The histological changes in section of testis and epididymis after treatment were observed. Sperm count in epididymis and fructose content in seminal vesicles were also measured. Levels of hormones like FSH, LH, and T were determined. A dose-dependent increase in sexual behaviors was evidenced in the animals of extract treated groups. Increase in testis weight was recorded in PT. At the highest dose PT also affects the hormones level. The four compounds namely puerarin, daidzein, biochanin-A and formononetin were identified in ethanolic extract using LC-MS. It concluded that PT extract possesses androgenic effect and it significantly increased the sexual behaviour and hormones level.http://dx.doi.org/10.1155/2013/780659 |
| spellingShingle | Nagendra Singh Chauhan Vikas Sharma Mayank Thakur Alexandra Christine Helena Frankland Sawaya V. K. Dixit Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade The Scientific World Journal |
| title | Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade |
| title_full | Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade |
| title_fullStr | Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade |
| title_full_unstemmed | Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade |
| title_short | Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade |
| title_sort | pueraria tuberosa dc extract improves androgenesis and sexual behavior via fsh lh cascade |
| url | http://dx.doi.org/10.1155/2013/780659 |
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