Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock
Background and aimsAnemia has been implicated in prognosis across ischemic heart diseases. This study aimed to investigate the association between time-weighted average hemoglobin (TWA-Hb) and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS).Methods...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1516100/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849727606482534400 |
|---|---|
| author | Xia Liu Tianbo Gong Yongpeng Zhang |
| author_facet | Xia Liu Tianbo Gong Yongpeng Zhang |
| author_sort | Xia Liu |
| collection | DOAJ |
| description | Background and aimsAnemia has been implicated in prognosis across ischemic heart diseases. This study aimed to investigate the association between time-weighted average hemoglobin (TWA-Hb) and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS).Methods and resultsWe conducted a retrospective analysis of 765 patients diagnosed with AMI-CS using data from the MIMIC-IV database (2008–2019). Kaplan–Meier survival analysis demonstrated that lower TWA-Hb levels were associated with higher cumulative mortality rates at 28 days, 90 days, 6 months, and 1 year (log-rank P = 0.002, 0.006, 0.048, and 0.005, respectively). Landmark analyses further revealed a sustained increase in mortality risk associated with lower TWA-Hb during the 28-day to 1-year follow-up period. Multivariable Cox regression analysis identified low TWA-Hb as an independent predictor of mortality risk at 90 days (P = 0.026), 6 months (P = 0.023), and 1 year (P = 0.021). Each one-unit increase in TWA-Hb was associated with a 0.93-, 0.76- and 0.71-fold decrease in the risk of 90-day, 6-month, and 1-year mortality, correspondingly. Subgroup analyses stratified by age, BMI, and comorbidities consistently supported these findings (all P < 0.05).ConclusionLow TWA-Hb is associated with long-term mortality in patients with AMI-CS. These findings imply that the application of this indicator in clinical practice could improve long-term risk stratification. |
| format | Article |
| id | doaj-art-4027f0d6f91f4ca2ae7c7d8677652e9f |
| institution | DOAJ |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-4027f0d6f91f4ca2ae7c7d8677652e9f2025-08-20T03:09:48ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-05-011210.3389/fcvm.2025.15161001516100Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shockXia LiuTianbo GongYongpeng ZhangBackground and aimsAnemia has been implicated in prognosis across ischemic heart diseases. This study aimed to investigate the association between time-weighted average hemoglobin (TWA-Hb) and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS).Methods and resultsWe conducted a retrospective analysis of 765 patients diagnosed with AMI-CS using data from the MIMIC-IV database (2008–2019). Kaplan–Meier survival analysis demonstrated that lower TWA-Hb levels were associated with higher cumulative mortality rates at 28 days, 90 days, 6 months, and 1 year (log-rank P = 0.002, 0.006, 0.048, and 0.005, respectively). Landmark analyses further revealed a sustained increase in mortality risk associated with lower TWA-Hb during the 28-day to 1-year follow-up period. Multivariable Cox regression analysis identified low TWA-Hb as an independent predictor of mortality risk at 90 days (P = 0.026), 6 months (P = 0.023), and 1 year (P = 0.021). Each one-unit increase in TWA-Hb was associated with a 0.93-, 0.76- and 0.71-fold decrease in the risk of 90-day, 6-month, and 1-year mortality, correspondingly. Subgroup analyses stratified by age, BMI, and comorbidities consistently supported these findings (all P < 0.05).ConclusionLow TWA-Hb is associated with long-term mortality in patients with AMI-CS. These findings imply that the application of this indicator in clinical practice could improve long-term risk stratification.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1516100/fullhemoglobinacute myocardial infarctioncardiogenic shockall-cause mortalityanemia |
| spellingShingle | Xia Liu Tianbo Gong Yongpeng Zhang Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock Frontiers in Cardiovascular Medicine hemoglobin acute myocardial infarction cardiogenic shock all-cause mortality anemia |
| title | Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock |
| title_full | Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock |
| title_fullStr | Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock |
| title_full_unstemmed | Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock |
| title_short | Association between time-varying weighted hemoglobin and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock |
| title_sort | association between time varying weighted hemoglobin and all cause mortality in patients with acute myocardial infarction related cardiogenic shock |
| topic | hemoglobin acute myocardial infarction cardiogenic shock all-cause mortality anemia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1516100/full |
| work_keys_str_mv | AT xialiu associationbetweentimevaryingweightedhemoglobinandallcausemortalityinpatientswithacutemyocardialinfarctionrelatedcardiogenicshock AT tianbogong associationbetweentimevaryingweightedhemoglobinandallcausemortalityinpatientswithacutemyocardialinfarctionrelatedcardiogenicshock AT yongpengzhang associationbetweentimevaryingweightedhemoglobinandallcausemortalityinpatientswithacutemyocardialinfarctionrelatedcardiogenicshock |