Organ preservation strategies for rectal cancer treatment: tarts or trap?
Total mesorectal excision (TME) is the standard treatment for advanced mid- and low-rectal cancer. However, the associated surgical complications and subsequent impairment of organ function limit its application. In recent years, with advancements in neoadjuvant chemoradiotherapy and the implementat...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Surgery Concepts & Practice
2024-09-01
|
| Series: | Waike lilun yu shijian |
| Subjects: | |
| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1737619500094-1066784943.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590598763184128 |
|---|---|
| author | ZHOU Yihang, ZENG Ziwei, KANG Liang |
| author_facet | ZHOU Yihang, ZENG Ziwei, KANG Liang |
| author_sort | ZHOU Yihang, ZENG Ziwei, KANG Liang |
| collection | DOAJ |
| description | Total mesorectal excision (TME) is the standard treatment for advanced mid- and low-rectal cancer. However, the associated surgical complications and subsequent impairment of organ function limit its application. In recent years, with advancements in neoadjuvant chemoradiotherapy and the implementation of immunotherapy, the pathological complete response (pCR) rate following neoadjuvant therapy for rectal cancer has significantly increased. This has raised questions about the necessity of performing TME in patients who achieve pCR. So as to, the clinical exploration of organ preservation strategies without radical surgery has been used in clinic. Current limited studies indicated that approaches such as watch & wait (W&W) or local excision have shown promising results in terms of long-term survival, and reduced surgical complications and functional impairment in some patients. However, challenges remain, including the difficulty in accurately assessing clinical complete response and the high rate of local recurrence, which could potentially compromise long-term survival. Further research into organ preservation strategies is needed, and careful consideration should be given to individual cases to prevent these strategies from becoming more of a “trap” than a “tart”. |
| format | Article |
| id | doaj-art-40278379f8a5409788e908c7c90293a0 |
| institution | Kabale University |
| issn | 1007-9610 |
| language | zho |
| publishDate | 2024-09-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj-art-40278379f8a5409788e908c7c90293a02025-01-23T10:48:45ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102024-09-01290539640010.16139/j.1007-9610.2024.05.05Organ preservation strategies for rectal cancer treatment: tarts or trap?ZHOU Yihang, ZENG Ziwei, KANG Liang0Department of Colorectal Surgery, Guangdong Institute of Gastroenterology，Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Guangzhou 510655, ChinaTotal mesorectal excision (TME) is the standard treatment for advanced mid- and low-rectal cancer. However, the associated surgical complications and subsequent impairment of organ function limit its application. In recent years, with advancements in neoadjuvant chemoradiotherapy and the implementation of immunotherapy, the pathological complete response (pCR) rate following neoadjuvant therapy for rectal cancer has significantly increased. This has raised questions about the necessity of performing TME in patients who achieve pCR. So as to, the clinical exploration of organ preservation strategies without radical surgery has been used in clinic. Current limited studies indicated that approaches such as watch & wait (W&W) or local excision have shown promising results in terms of long-term survival, and reduced surgical complications and functional impairment in some patients. However, challenges remain, including the difficulty in accurately assessing clinical complete response and the high rate of local recurrence, which could potentially compromise long-term survival. Further research into organ preservation strategies is needed, and careful consideration should be given to individual cases to prevent these strategies from becoming more of a “trap” than a “tart”.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1737619500094-1066784943.pdf|rectal cancer|neoadjuvant therapy|watch & wait(w&w)|local excision |
| spellingShingle | ZHOU Yihang, ZENG Ziwei, KANG Liang Organ preservation strategies for rectal cancer treatment: tarts or trap? Waike lilun yu shijian |rectal cancer|neoadjuvant therapy|watch & wait(w&w)|local excision |
| title | Organ preservation strategies for rectal cancer treatment: tarts or trap? |
| title_full | Organ preservation strategies for rectal cancer treatment: tarts or trap? |
| title_fullStr | Organ preservation strategies for rectal cancer treatment: tarts or trap? |
| title_full_unstemmed | Organ preservation strategies for rectal cancer treatment: tarts or trap? |
| title_short | Organ preservation strategies for rectal cancer treatment: tarts or trap? |
| title_sort | organ preservation strategies for rectal cancer treatment tarts or trap |
| topic | |rectal cancer|neoadjuvant therapy|watch & wait(w&w)|local excision |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1737619500094-1066784943.pdf |
| work_keys_str_mv | AT zhouyihangzengziweikangliang organpreservationstrategiesforrectalcancertreatmenttartsortrap |